Registration Dossier
Registration Dossier
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EC number: 225-863-2 | CAS number: 5124-30-1
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.003 mg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 1.91 mg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 2.93 mg/kg sediment dw
- Assessment factor:
- 100
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.293 mg/kg sediment dw
- Assessment factor:
- 1 000
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 2.38 mg/kg soil dw
- Assessment factor:
- 100
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
The following table shows the results of the acute ecotox tests:
Results of acute ecotoxicological tests:
|
Highest concentration tested with no effect in mg/L (EC/LC0) |
EC/LC50 |
Remarks |
fish |
8.1 |
>8.1 |
|
invertebrates |
8.3 |
>8.3 |
|
algae |
5 |
>5 |
72 h-ErC50 |
Since there are acute test results available for 4,4’-methylenedicyclohexyl diisocyanate (which include the hydrolysis product) from three trophic levels, an assessment factor of 1000 would be applicablefor the derivation of the PNECaqua according to the REACH Guidance Document (ECHA 2008). The reported NOEC value is indeed statistically significant, but not from a biological point of view. T
Conclusion on classification
The substance is rapidly degradable (hydrolysis). The hydrolysis product is - beside insoluble oligomeric and polymeric ureas - the corresponding 4,4´-Methylenedicyclohexyl diamine. As the half life of the parent substance was determined to be 2 h and as the test solutions were stirred for 24 h it can be assumed that only the hydrolysis products were present in the test solutions and thus potential effects were caused by the hydrolysis products rather than by the parent substance.
Classification according to Regulation 1272/2008
The substance is not to be classified acutely hazardous to the aquatic environment, since no acute effects are reported. Chronic data are given for algae, however they are considered to be not relevant. Furthermore the substance degrades rapidly with a half-life of about 2 hours, no classification is required based on chronic toxicity data.
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