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EC number: 225-863-2 | CAS number: 5124-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
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- Nanomaterial pour density
- Nanomaterial photocatalytic activity
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- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
Aquatic bioaccumulation
4,4’-Methylenedicyclohexyl diisocyanate is characterized by a BCF of 10186 being calculated with BCFWIN v. 2.17 (Currenta, 2009a). However, the direct and indirect exposure of aquatic organisms is unlikely because 4,4’-methylenedicyclohexyl diisocyanate hydrolysis rapidly in water within 2 hours (half-life 1.97 hours).
The hydrolysis product of 4,4’-methylenedicyclohexyl diisocyanate with a calculated bioconcentration factor of 7.3 does not have a high bioaccumulation potential (Currenta, 2009b).
The following information is taken into account for any hazard / risk / bioaccumulation assessment:
4,4'-Methylenedicyclohexyl diisocyanate hydrolyses rapidly in the presence of water with a half life of approximately 2 hours. Therefore a risk estimation regarding the bioaccumulation potential of 4,4'methylenedicyclohexyl diisocyanate on the basis of a log Kow or a BCF, determined by QSAR, is misleading. A calculated theoretical log Kow or BCF value reflects the undissociated and unreacted molecule without influence of water.
However, the substance is not persistent in water due to the rapid hydrolysis. Therefore it is not bio-available. Possible hydrolysis products are less lipophilic. On the basis of these information it can be expected that relevant bioaccumulation of 4,4'-methylenedicyclohexyl diisocyanate does not occur.
Terrestrial
bioaccumulation
Not applicable.
Secondary poisoning
Because of the rapid hydrolysis of 4,4'-methylenedicyclohexyl diisocyanate in water, it is not expected that this substance will bioconcentrate in aquatic organisms, or bioaccumulate in the food chain. No information on BCFs and food chain bioaccumulation could be found for 4,4'-methylenedicyclohexyl diisocyanate in the available literature; however, a BCF of approximately 7 was calculated for the hydrolysis product 4,4’-methylenedicyclohexyl diamine (CAS number 1761-71-3) which indicates a very low bioaccumulation potential. For this reason, there is no risk for secondary poisoning. It is not required to carry out a risk characterisation for secondary poisoning.
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