Registration Dossier
Registration Dossier
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EC number: 202-445-8 | CAS number: 95-73-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No guideline followed but well documented inhouse procedure
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Benzene, 2,4-dichloro-1-methyl-
- IUPAC Name:
- Benzene, 2,4-dichloro-1-methyl-
- Reference substance name:
- 2,4-dichlorotoluene
- EC Number:
- 202-445-8
- EC Name:
- 2,4-dichlorotoluene
- Cas Number:
- 95-73-8
- Molecular formula:
- C7H6Cl2
- IUPAC Name:
- 2,4-dichloro-1-methylbenzene
- Details on test material:
- 2,4-Dichlorotoluene rein 99 %. State of matter: liquid.
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Test animals:
Wistar rats, males and females. The females were 14 weeks old, the males were 9 weeks old at the beginning of the test. Average weight at the beginning of the test: 177 g.
Tested in groups of 5 animals.
Conditions: 22 +/- 1.5°C; 12h light/dark cycle; humidity 60 +/- 5% .
Source: Winkelmann, Borchen.
Feed: Altromin R 1324 and tap water ad libitum.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The test substance was administered unchanged by gavage.
The mixture was given once on the beginning of the test. - Doses:
- 1,0 ml/kg bw; 1,5 ml/kg bw; 2,0 ml/kg bw; 2,5 ml/kg bw; 3,5 ml/kg bw
- No. of animals per sex per dose:
- 5 per sex per dose
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2.23 mL/kg bw
Applicant's summary and conclusion
- Conclusions:
- The LD50 value for acute oral toxicity is 2,23 ml/kg bw in Wistar (males and females) rats.
The LD50 value for acute oral toxicity is 2788 mg/kg bw in Wistar (males and females) rats (the value is calculated based on the density)
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