Registration Dossier
Registration Dossier
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EC number: 202-445-8 | CAS number: 95-73-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzene, 2,4-dichloro-1-methyl-
- IUPAC Name:
- Benzene, 2,4-dichloro-1-methyl-
- Reference substance name:
- 2,4-dichlorotoluene
- EC Number:
- 202-445-8
- EC Name:
- 2,4-dichlorotoluene
- Cas Number:
- 95-73-8
- Molecular formula:
- C7H6Cl2
- IUPAC Name:
- 2,4-dichloro-1-methylbenzene
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- The substance was applied to the skin of the abdomen. The test site was intact or scarified.
- Doses:
- 316 – 10 000 mg/kg bw.
- Control animals:
- not specified
- Details on study design:
- In a acute dermal toxicity study (Hazleton Laboratories, Virginia, 1972) 2 New Zealand White rabbits were dermally exposed to 2,4-dichlorotoluene (pure).The substance was applied to the skin of the abdomen. The test site was intact or scarified.
Doses: 316 – 10 000 mg/kg bw.
Period of exposure: 24 hours
Observation period after exposure: 7 days.
No animals died during the test.
No signs of systemic toxicity were observed.
The skin showed slight to moderate erythema, oedemas, temporary bleaching and desquamation over the treated area.
The value of the dermal toxicity was determined to be > 10 000 mg/kg bw.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 10 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No animals died during the test.
- Other findings:
- The skin showed slight to moderate erythema, oedemas, temporary bleaching and desquamation over the treated area.
Applicant's summary and conclusion
- Conclusions:
- The value of the dermal toxicity LD50 was determined to be > 10 000 mg/kg bw.
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