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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Referred in a recognized source of peer reviewed scientific data on chemicals

Data source

Reference
Reference Type:
review article or handbook
Title:
Experimental acute toxicity of vinyl Chloride (monochloroethene).
Author:
Prodan L, Suciu I, Pîslaru V, Ilea E, & Pascu L
Year:
1975
Bibliographic source:
Ann NY Acad Sci, 246: 154–158.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: no data
GLP compliance:
not specified
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
Chloroethylene
EC Number:
200-831-0
EC Name:
Chloroethylene
Cas Number:
75-01-4
Molecular formula:
C2H3Cl
IUPAC Name:
chloroethene

Test animals

Species:
other: rodents

Administration / exposure

Route of administration:
inhalation: gas
Type of inhalation exposure:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LC50
Effect level:
390 mg/m³ air
Exp. duration:
2 h
Remarks on result:
other: rats
Sex:
not specified
Dose descriptor:
LC50
Effect level:
293 mg/m³ air
Exp. duration:
2 h
Remarks on result:
other: mice
Sex:
not specified
Dose descriptor:
LC50
Effect level:
595 mg/m³ air
Exp. duration:
2 h
Remarks on result:
other: Guinea-pigs
Sex:
not specified
Dose descriptor:
LC50
Effect level:
295 mg/m³ air
Remarks on result:
other: rabbits

Any other information on results incl. tables

Overview of experimental studies on acute toxicity of chloroethylene after inhalation

Method

 

Results

Remarks

Reference

Rodents, inhalation

Guideline: not known

LC50 (2-h, rats)=390 000 mg/m3;

LC50 (2-h, mice)=293 000 mg/m3

LC50 (2-h, Guinea-pigs)=595 000 mg/m3

LC50 (2-h, rabbits)=295 000 mg/m3

 

 

Peer-reviewed data summarised in the World Health Organization (WHO) review report of vinyl chloride

 

Prodan L, Suciu I, Pîslaru V, Ilea E, & Pascu L (1975) Experimental acute toxicity of vinyl

Chloride (monochloroethene). Ann NY Acad Sci, 246: 154–158.

Applicant's summary and conclusion

Conclusions:
The cut-off value for classification of substances for acute inhalation toxicity for gases is LC50= 20 000 ppm (v/v). All published data for chloroethylene report LC50 values higher than 20 000 ppm.
It is, therefore, considered that chloroethylene is of low acute toxicity in experimental animals by inhalation.