Registration Dossier
Registration Dossier
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EC number: 201-944-8 | CAS number: 89-83-8
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: only abstract available, original literature in Japanese
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of phenolic dental medications on arachidonic acid metabolism and their anti-inflammatory action
- Author:
- Anamura S
- Year:
- 1 989
- Bibliographic source:
- Hiroshima Daigaku Shigaku Zasshi 21, 147-162
Materials and methods
- Principles of method if other than guideline:
- anti-inflammatory effect of thymol
- GLP compliance:
- no
- Type of method:
- other: in-vivo and in-vitro
- Endpoint addressed:
- not applicable
Test material
- Reference substance name:
- Thymol
- EC Number:
- 201-944-8
- EC Name:
- Thymol
- Cas Number:
- 89-83-8
- Molecular formula:
- C10H14O
- IUPAC Name:
- 5-methyl-2-(propan-2-yl)phenol
- Details on test material:
- Test substance: Thymol (no data on purity)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: no data
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- no data
- Frequency of treatment:
- no data
- Post exposure period:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
no data
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
- Details on results:
- The phenolic dental medications thymol etc. had anti-inflammatory effect against croton oil-induced ear edema in mice
Any other information on results incl. tables
In vitro studies in rabbit and bovine kidney medulla and tooth pulp microsomes and homogenates, rat tooth pulp homogenates, and human leucocytes indicated that the phenols inhibit PG and leucotriene biosynthesis in arachidonic acid metabolites, which may be the mechanism of their anit-inflammatory actions.
Applicant's summary and conclusion
- Executive summary:
The phenolic dental medications thymol etc. had anti-inflammatory effect against croton oil-induced ear edema in mice.
In vitro studies in rabbit and bovine kidney medulla and tooth pulp microsomes and homogenates, rat tooth pulp homogenates, and human leucocytes indicated that the phenols inhibit PG and leucotriene biosynthesis in arachidonic acid metabolites, which may be the mechanism of their anit-inflammatory actions.
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