Registration Dossier
Registration Dossier
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EC number: 210-848-5 | CAS number: 624-48-6
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 19.4 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: ECHA REACH guidance & ECETOC T110 (2010)
- Overall assessment factor (AF):
- 10.3
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 1 400 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- NOAEL(oral) = 200 mg/kg bw/day; body weight: 70 kg; 10 m3 breathing volume/working day
- AF for differences in duration of exposure:
- 6
- Justification:
- Sub acute – chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- rat - human
- AF for intraspecies differences:
- 3
- Justification:
- workers (ECETOC)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.83 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- other: ECHA REACH Guidance and ECETOC T110 (2010)
- Overall assessment factor (AF):
- 72
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 60 mg/kg bw/day
- AF for differences in duration of exposure:
- 6
- Justification:
- subactue - chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- rat - human
- AF for intraspecies differences:
- 3
- Justification:
- workers
Acute/short term exposure
- Hazard assessment conclusion:
- no DNEL required: short term exposure controlled by conditions for long-term
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- sensitisation (skin)
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
Acute/short term exposure
- Hazard assessment conclusion:
- no DNEL required: short term exposure controlled by conditions for long-term
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
to be filled in
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