Registration Dossier
Registration Dossier
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EC number: 210-848-5 | CAS number: 624-48-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1977
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Dimethyl maleate
- EC Number:
- 210-848-5
- EC Name:
- Dimethyl maleate
- Cas Number:
- 624-48-6
- Molecular formula:
- C6H8O4
- IUPAC Name:
- dimethyl (Z)-but-2-enedioate
- Details on test material:
- no data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Amount / concentration applied:
- 100 µL
- Observation period (in vivo):
- 7 days p.a.
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- Instillation into the conjunctival sac of the eyes.
Results and discussion
In vivo
- Irritant / corrosive response data:
- highly irritating
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- The test item was highly irritating to the eyes of rabbits.
- Executive summary:
0.1 mL substance was instilled into the conjunctival sac of rabbits, which were observed for 7 days.
The test item was highly irritating.
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