Registration Dossier
Registration Dossier
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EC number: 213-607-2 | CAS number: 993-13-5
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No details on test method provided.
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Test type:
- not specified
- Water media type:
- not specified
- Total exposure duration:
- 48 h
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 3.273 mg/L
- Conclusions:
- The 48h EC50 of MPA to Daphnia magna was reported to be 3.273 mg/L.
Reference
Description of key information
Resulting from a valid acute Daphnia toxicity study (Kamp 1995) with read across substance MPAAU according to OECD-Test Guideline 202 the EC50 values were calculated as being 780 and 700 mg test item/L measured after 24h and 48h, respectively. Therefore, the EC50 values for the active substance can be calculated for 24h with 390 mg/L and for 48h with 350 mg/L.
The acute Daphnia study of Williams 1987 was conducted with the target substance itself.
However, the review article of Munro et al. (1999) is giving no further information than the mere result. But these data only are known from this single secondary literature source, it is furthermore not possible to verify the correctness of the data by a second independent data source. Because of this, further attempts were undertaken to retrieve the original study report from U.S. military web services (USCEHR, NTIS), but unfortunately without success.
With no further clarification on data reliability possible, this renders the reliability of the acute Daphnia toxicity study of Williams (1987) as not assignable (Klimisch 4).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 350 mg/L
Additional information
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