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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
weight of evidence
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
no guideline followed
Principles of method if other than guideline:
No details on test method provided.
GLP compliance:
not specified
Analytical monitoring:
not specified
not specified
Test organisms (species):
Daphnia magna
Test type:
not specified
Water media type:
not specified
Total exposure duration:
48 h
48 h
Dose descriptor:
Effect conc.:
3.273 mg/L
The 48h EC50 of MPA to Daphnia magna was reported to be 3.273 mg/L.

Description of key information

Resulting from a valid acute Daphnia toxicity study (Kamp 1995) with read across substance MPAAU according to OECD-Test Guideline 202 the EC50 values were calculated as being 780 and 700 mg test item/L measured after 24h and 48h, respectively. Therefore, the EC50 values for the active substance can be calculated for 24h with 390 mg/L and for 48h with 350 mg/L.

The acute Daphnia study of Williams 1987 was conducted with the target substance itself.

However, the review article of Munro et al. (1999) is giving no further information than the mere result. But these data only are known from this single secondary literature source, it is furthermore not possible to verify the correctness of the data by a second independent data source. Because of this, further attempts were undertaken to retrieve the original study report from U.S. military web services (USCEHR, NTIS), but unfortunately without success.

With no further clarification on data reliability possible, this renders the reliability of the acute Daphnia toxicity study of Williams (1987) as not assignable (Klimisch 4).

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
350 mg/L

Additional information