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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

toxicity to aquatic algae and cyanobacteria
Type of information:
experimental study
Adequacy of study:
weight of evidence
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
no guideline followed
Principles of method if other than guideline:
No details on materials and methods provided
GLP compliance:
not specified
Analytical monitoring:
not specified
not specified
Test type:
not specified
Water media type:
not specified
14 d
Dose descriptor:
Effect conc.:
17.805 mg/L
Th 14d EC50 was reported to be 17.805 mg/L.

Description of key information

Acute toxicity for freshwater algae Pseudokirchneriella subcapitata (growth rate):
72h-EC50 = 43.1 mg MPAAU/L
72h-EC10 = 13.5 mg MPAAU/L
72h-NOEC = 3.2 mg MPAAU /L

Key value for chemical safety assessment

EC50 for freshwater algae:
43.1 mg/L
EC10 or NOEC for freshwater algae:
13.5 mg/L

Additional information

A valid algal growth inhibition study (Kley 2012) with read across substance MPAAU revealed following results for growth rate: 72h-EC50 = 43.1 mg/L, 72h-EC10 = 13.5 mg/L, 72h-NOEC value = 3.2 mg/L. The algae therefore has been to be the most sensitive of the tested freshwater organisms.

The algal growth inhibition study of Williams 1987 was conducted with the target substance itself. However, the review article of Munro et al. (1999) is giving no further information than the mere result. But these data only are known from this single secondary literature source, it is furthermore not possible to verify the correctness of the data by a second independent data source. Because of this, further attempts were undertaken to retrieve the original study report from U.S. military web services (USCEHR, NTIS), but unfortunately without success. With no further clarification on data reliability possible, this renders the reliability of the acute algal growth inhibition study of Williams (1987) as not assignable (Klimisch 4).