Registration Dossier
Registration Dossier
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EC number: 213-607-2 | CAS number: 993-13-5
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Refer chapter 13 for detailed read across justification.
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Evaluation of toxicokinetic behaviour based on structure and physico-chemical and toxicological properties of the substance.
- Adequacy of study:
- key study
- Study period:
- 2012-06-29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Evaluation of toxicokinetic behaviour based on structure and physico-chemical and toxicological properties of the substance.
- Objective of study:
- toxicokinetics
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- assessment of toxicokinetic behaviour
- GLP compliance:
- no
- Conclusions:
- MPAAU is expected to have good bioavailability after uptake via the oral and inhalation route. Based on data of an in-vitro dermal penetration test the bioavailability via the dermal route is low (<5%). MPAAU as well as so far unidentified metabolites are expected to be widely distributed in the organism without potential of bioaccumulation. Excretion via urine is regarded to be the preferred way of elimination.
There are indications from available toxicity studies that MPAAU was absorbed and distributed systemically when administered orally. Short-term toxicity studies with relatively large doses of MPAAU suggest that absorbed MPAAU and potential metabolites are rapidly eliminated without impact to the test animals. MPAAU and its potential metabolites do not present a genotoxic hazard and do not cause significant toxicity in animals.
Bioaccumulation is not expected because of the low log Pow.
Data source
Materials and methods
- Objective of study:
- toxicokinetics
- GLP compliance:
- no
Test material
- Reference substance name:
- Methylphosphonic acid
- EC Number:
- 213-607-2
- EC Name:
- Methylphosphonic acid
- Cas Number:
- 993-13-5
- Molecular formula:
- CH5O3P
- IUPAC Name:
- methylphosphonic acid
- Reference substance name:
- methyl phosphonic acid
- Cas Number:
- 993-13-5
- IUPAC Name:
- methyl phosphonic acid
- Test material form:
- not specified
- Details on test material:
- no data
Constituent 1
Constituent 2
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- MPAAU is expected to have good bioavailability after uptake via the oral and inhalation route. Based on data of an in-vitro dermal penetration test the bioavailability via the dermal route is low (<5%). MPAAU as well as so far unidentified metabolites are expected to be widely distributed in the organism without potential of bioaccumulation. Excretion via urine is regarded to be the preferred way of elimination.
There are indications from available toxicity studies that MPAAU was absorbed and distributed systemically when administered orally. Short-term toxicity studies with relatively large doses of MPAAU suggest that absorbed MPAAU and potential metabolites are rapidly eliminated without impact to the test animals. MPAAU and its potential metabolites do not present a genotoxic hazard and do not cause significant toxicity in animals.
Bioaccumulation is not expected because of the low log Pow.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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