Registration Dossier
Registration Dossier
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EC number: 210-180-4 | CAS number: 609-15-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: study performed according to GLP and OECD guidelines
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Ethyl 2-chloroacetoacetate
- EC Number:
- 210-180-4
- EC Name:
- Ethyl 2-chloroacetoacetate
- Cas Number:
- 609-15-4
- Molecular formula:
- C6H9ClO3
- IUPAC Name:
- ethyl 2-chloro-3-oxobutanoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: HanIbm WIST
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 100, 500, 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 233 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 15 - <= 661
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 646 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 274 - <= 2 761
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 402 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 205 - <= 812
Any other information on results incl. tables
no other information
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- the mean lethal dose for the acute oral toxicity of Chloracetessigester in rats of females for a period of 14 days is 233 mg/kg/bw
- Executive summary:
The testarticle Chloracetessigester was administered to three groups of 5 male and 5 female rats by oral gavage, at single doses from 100 to 2000 mg /kg body weigh
The mean lethal dose for the acute oral toxicity of Chloracetessigester in rats of females for a period of 14 days is 233 mg/kg/bw.
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