Registration Dossier
Registration Dossier
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EC number: 222-048-3 | CAS number: 3327-22-8
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Rapporteur for the EU risk assessment of (3-chloro-2-hydroxypropyl)trimethylammonium chloride is the National Product Control Agency for Welfare and Health, Finland. The report is the result of in-depth work performed by experts in one Member State, working with counterparts in other Member States, Industry and public interest groups. The information reported is considered reliable.
Data source
Reference
- Reference Type:
- other: Published secondary source
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- (3-chloro-2-hydroxypropyl)trimethylammonium chloride
- EC Number:
- 222-048-3
- EC Name:
- (3-chloro-2-hydroxypropyl)trimethylammonium chloride
- Cas Number:
- 3327-22-8
- Molecular formula:
- C6H15ClNO.Cl
- IUPAC Name:
- 3-chloro-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
Study design
- Test type:
- semi-static
- Water media type:
- not specified
- Total exposure duration:
- 96 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 4 128 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 2 094 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- not specified
Applicant's summary and conclusion
- Conclusions:
- (3-chloro-2-hydroxypropyl)trimethylammonium chloride is very slightly toxic to fish. In a short-term toxicity study the nominal LC50 value for fish is 4128 mg/L. The pH ranged from 6.5-8.0 and pH lower than 7.0 was observed with the highest test concentration (10000 mg/L nominal).
- Executive summary:
(3-chloro-2-hydroxypropyl)trimethylammonium chloride is very slightly toxic to fish. In a short-term toxicity study the nominal LC50 value for fish is 4128 mg/L. The pH ranged from 6.5-8.0 and pH lower than 7.0 was observed with the highest test concentration (10000 mg/L nominal).
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