Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Endpoint conclusion:
no study available
Effect on fertility: via inhalation route
Endpoint conclusion:
no study available
Effect on fertility: via dermal route
Endpoint conclusion:
no study available
Additional information
Short description of key information:
No reproductive toxicity data is available for dichloromethyl(3,3,3-trifluoropropyl)silane. The hazard profile of dichloromethyl(3,3,3-trifluoropropyl)silane is solely driven by the hydrolysis product HCl and can be assessed qualitatively and quantitatively by considering the amount of HCl produced by hydrolysis. Further repeated-dose animal studies should be omitted due to animal welfare.

Justification for selection of Effect on fertility via oral route:
Dichloromethyl(3,3,3-trifluoropropyl)silane (CAS 675-62-7) is a highly moisture-sensitive liquid that hydrolyses rapidly in contact with water (half-life of 8 to 12 seconds at pH 4, 7 and 9 at 1.5°C) to methyl(3,3,3-trifluoropropyl)silanediol and hydrogen chloride (HCl). As the substance is corrosive, risk management measures are in place at industrial sites to prevent the potential for human exposure to dichloromethyl(3,3,3-trifluoropropyl)silane. Due to the corrosive nature of the substance it is considered not to be either ethical or scientifically justified to perform repeated dose toxicity testing with dichloromethyl(3,3,3-trifluoropropyl)silane by any route of exposure. As an example, following repeated oral dosing, the corrosive nature of the product could affect the lining of the stomach, giving rise to hyperplasia and a subsequent reduced food intake. This would make the interpretation of any systemic findings difficult.

Justification for selection of Effect on fertility via inhalation route:
A guideline-compliant repeated-dose inhalation study should elicit systemic toxicity at the highest test concentration. Since the local corrosive effects of dichloromethyl(3,3,3-trifluoropropyl)silane would be significant, it is unlikely that any systemic effects would be seen at dose levels made sufficiently low (< 10 ppm) to prevent the known corrosive effects and/or distress in the test species.

Justification for selection of Effect on fertility via dermal route:
In accordance with Section 2 of REACH Annex XI testing for reproductive toxicity (required in Section 8.7.3) will be omitted because it is technically not feasible.
The known corrosive effects of dichloromethyl(3,3,3-trifluoropropyl)silane mean that testing via all routes at suitable dose levels would lead to severe local effects and significant distress in the test species.

Effects on developmental toxicity

Description of key information
No developmental toxicity data is available for dichloromethyl(3,3,3-trifluoropropyl)silane. The hazard profile of dichloromethyl(3,3,3-trifluoropropyl)silane is solely driven by the hydrolysis product HCl and can be assessed qualitatively and quantitatively by considering the amount of HCl produced by hydrolysis. Further repeated-dose animal studies should be omitted due to animal welfare.
Effect on developmental toxicity: via oral route
Endpoint conclusion:
no study available
Effect on developmental toxicity: via inhalation route
Endpoint conclusion:
no study available
Effect on developmental toxicity: via dermal route
Endpoint conclusion:
no study available
Additional information
Justification for selection of Effect on developmental toxicity: via oral route:
Dichloromethyl(3,3,3-trifluoropropyl)silane (CAS 675-62-7) is a highly moisture-sensitive liquid that hydrolyses rapidly in contact with water (half-life of 8 to 12 seconds at pH 4, 7 and 9 at 1.5°C) to methyl(3,3,3-trifluoropropyl)silanediol and hydrogen chloride (HCl). As the substance is corrosive, risk management measures are in place at industrial sites to prevent the potential for human exposure to dichloromethyl(3,3,3-trifluoropropyl)silane. Due to the corrosive nature of the substance it is considered not to be either ethical or scientifically justified to perform repeated dose toxicity testing with dichloromethyl(3,3,3-trifluoropropyl)silane by any route of exposure. As an example, following repeated oral dosing, the corrosive nature of the product could affect the lining of the stomach, giving rise to hyperplasia and a subsequent reduced food intake. This would make the interpretation of any systemic findings difficult.

Justification for selection of Effect on developmental toxicity: via inhalation route:
A guideline-compliant repeated-dose inhalation study should elicit systemic toxicity at the highest test concentration. Since the local corrosive effects of dichloromethyl(3,3,3-trifluoropropyl)silane would be significant, it is unlikely that any systemic effects would be seen at dose levels made sufficiently low (< 10 ppm) to prevent the known corrosive effects and/or distress in the test species.

Justification for selection of Effect on developmental toxicity: via dermal route:
In accordance with Section 2 of REACH Annex XI testing for reproductive toxicity (required in Section 8.7.3) will be omitted because it is technically not feasible.
The known corrosive effects of dichloromethyl(3,3,3-trifluoropropyl)silane mean that testing via all routes at suitable dose levels would lead to severe local effects and significant distress in the test species.

Justification for classification or non-classification

In the absence of appropriate measured data, the substance is not classified for reproductive or developmental toxicity.

Additional information