Dichloromethyl(3,3,3-trifluoropropyl)silane

Endpoint summary

Description of key information

Skin irritation / corrosion: No data available (waiving according to Column 2 of REACH Annex VII (Section 8.1.1))
Eye irritation: No data available (waiving according to Column 2 of REACH Annex VII (Section 8.2.1))

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irritating)

Additional information

Dichloro(3,3,3 -fluoropropyl)silane hydrolyses very rapidly (half-life 12 seconds at pH 7) in contact with water and moist air, releasing 2 moles of hydrogen chloride (HCl) for one mole of parent material. Severe skin, eye and respiratory damage can be expected due to release of HCl. This is consistent with reliable measured data for other chlorosilanes

In a supporting skin irritation study (RL 4) study in two rabbits, which predates GLP and is equivalent or similar to OECD 404, severe dermal irritation was seen in both animals. Sloughing of skin, bleeding fissures and serous oozing were seen in both animals with mortality seen in the second rabbit at day 14 (DCC, 1967).

In a supporting eye irritation study (RL 4) study in two rabbits, which predates GLP and is equivalent or similar to OECD 405, severe eye irritation were seen in both animals. Conjunctival tissues of all rabbits was blanched (DCC, 1967).

Justification for selection of skin irritation / corrosion endpoint:
In accordance with Column 2 of REACH Annex VIII, the in vivo skin irritation study (required in Section 8.1.1) does not need to be conducted as the available information indicates that the substance meets the criteria for classification as corrosive to skin. Dichloro(3,3,3 -fluoropropyl)silane hydrolyses very rapidly (half-life 12 seconds at pH 7) in contact with water and moist air, releasing 2 moles of hydrogen chloride (HCl) for one mole of parent material. Severe skin, eye and respiratory damage can be expected due to release of HCl. This is consistent with reliable measured data for other chlorosilanes. However, a supporting study with limited documentation (only an abstract was available for review) reveals severe dermal irritation including loughing of skin, bleeding fissures and serous oozing.

Justification for selection of eye irritation endpoint:
In accordance with Column 2 of REACH Annex VIII, the in vivo eye irritation study (required in Section 8.2.1) does not need to be conducted as the substance is classified as corrosive to skin. Dichloro(3,3,3 -fluoropropyl)silane hydrolyses very rapidly (half-life 12 seconds at pH 7) in contact with water and moist air, releasing 2 moles of hydrogen chloride (HCl) for one mole of parent material. Severe skin, eye and respiratory damage can be expected due to release of HCl. This is consistent with reliable measured data for other chlorosilanes. However, a supporting study with limited documentation (only an abstract was available for review) reveals severe eye irritation including blanching of conjunctival tissues.

Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: corrosive

Effects on respiratory irritation: highly irritating

Justification for classification or non-classification

Dichloromethyl(3,3,3 -trifluoropropyl)silane is classified Skin Corr. 1A with hazard statement H314 ‘Causes severe skin burns and eye damage’ according to Regulation (EC) 1272/2008.

There are no reliable experimental data for skin or eye irritation/corrosion. Dichloromethyl(3,3,3 -trifluoropropyl)silane hydrolyses rapidly in contact with water and moist air, releasing two moles of hydrogen chloride (HCl) for each mole of parent material. Although no reliable in vivo irritation/corrosion studies are available, severe skin, eye and respiratory damage can be expected due to release of HCl. This is consistent with reliable measured data for other chlorosilanes.

There are no experimental data for respiratory tract irritation. The additional hazard statement EUH071 ‘Corrosive to the respiratory tract' (Regulation (EC) 1272/2008) is proposed in accordance with anticipated respiratory tract damage due to the hydrolysis product HCl generated by chlorosilanes on contact with moisture.