Dichloromethyl(3,3,3-trifluoropropyl)silane

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Only an abstract was available for review.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1967

Report date:

1967

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Deviations:

yes

Remarks:

Only 2 rabbits used and an exposure period of 24 hours was used.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Dichloromethyl(3,3,3-trifluoropropyl)silane

EC Number:

211-623-4

EC Name:

Dichloromethyl(3,3,3-trifluoropropyl)silane

Cas Number:

675-62-7

Molecular formula:

C4H7Cl2F3Si

IUPAC Name:

(dichloromethyl)(3,3,3-trifluoropropyl)silane

Details on test material:

- Name of test material (as cited in study report): Trifluoropropyl(methyl)dichlorosilane
- Substance type: Chlorosilane
- Physical state: Clear colourless liquid
- Lot/batch No.: TX183A

Test animals

Species:

rabbit

Strain:

other: Albino

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Maxfield animal supply, Ohio, USA

Test system

Type of coverage:

occlusive

Preparation of test site:

other: Intact

Vehicle:

unchanged (no vehicle)

Controls:

not required

Amount / concentration applied:

TEST MATERIAL
- Concentration (if solution): 2.0 ml/kg bw

Duration of treatment / exposure:

24 hours

Observation period:

14 days

Number of animals:

2

Details on study design:

TEST SITE
Each sample was introduced under a binder previously placed around the truck of the animal and secured with staples. The trunks of the animals were wrapped securely with gauze and adhesive tape to keep the binder and test material in contact with the skin and to prevent ingestion of the applied material.

REMOVAL OF TEST SUBSTANCE
- Washing: Any unabsorbed material remaining on the skin was removed by gentle sponging with a moistened towel.
- Time after start of exposure: 24 hours

SCORING SYSTEM: Draize scoring system

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

animal #1

Time point:

other: average 24 and 48 h

Score:

4

Max. score:

4

Reversibility:

not fully reversible within: 15 days

Remarks on result:

other: 24 h exposure

Results 2

Irritation parameter:

erythema score

Basis:

animal #2

Time point:

other: average 24 and 48 h

Score:

4

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: 24 h exposure, found dead on Day 14

Results 3

Irritation parameter:

edema score

Basis:

mean

Time point:

other: average 24 and 48 h

Score:

0

Max. score:

4

Reversibility:

other: no edema formation observed

Remarks on result:

other: 24 h exposure

Any other information on results incl. tables

Table 2.Dermal Irritation score

Skin	Day No.	Score for Rabbit No.
		1	2
Erythema and Eschar formation	1	4	4
	2	4	4
	6	4	4
	10	4	4
	14	4	Dead
	15	4
Edema formation	1	0	0
	2	0	0
	6	0	0
	10	0	0
	14	0	Dead
	15	0
Character of Dermal Irritation	Severe: Characterised by sloughing of skin, bleeding, fissures and serous oozing.

Applicant's summary and conclusion

Conclusions:

Severe dermal irritation were seen in both animals. Sloughing of skin, bleeding fissures and serous oozing were seen in both animals with mortality seen in the second rabbit at Day 14.