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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to microorganisms, other
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary literature
Qualifier:
according to guideline
Guideline:
other: Refer below principle
Principles of method if other than guideline:
Study was conducted to determine the effect of test chemical on the growth and cell proliferation of microorganisms Entosiphon sulcatum.
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
other: Entosiphon sulcatum
Details on inoculum:
Details on test organisms:
Color oser, bacterivorous flagellate cells were used
Test type:
static
Water media type:
other: Wastewater
Total exposure duration:
72 h
Test temperature:
25° C
pH:
6.9
Nominal and measured concentrations:
nominal concentration
Reference substance (positive control):
not specified
Key result
Duration:
72 h
Dose descriptor:
LOEC
Effect conc.:
40 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: cell proliferation inhibition
Remarks on result:
other: Other details not known
Validity criteria fulfilled:
not specified
Conclusions:
After the exposure of test chemical for 72 hrs, with microorganisms Entosiphon sulcatum, the LOEC was observed at 40 mg/l.
Executive summary:

Study was conducted to determine the effect of test chemical on the growth and cell proliferation of microorganisms Entosiphon sulcatum. Test conducted under the static system at 25° C. After the exposure of test chemical for 72 hrs, with microorganisms Entosiphon sulcatum, the LOEC was observed at 40 mg/l.

Description of key information

Study was conducted to determine the effect of test chemical on the growth and cell proliferation of microorganisms Entosiphon sulcatum. Test conducted under the static system at 25° C. After the exposure of test chemical for 72 hrs, with microorganisms Entosiphon sulcatum, the LOEC was observed at 40 mg/l.

Key value for chemical safety assessment

Additional information

Various studies available for the test chemical were reviewed to determine the toxic nature of test chemical on the growth and other activity of microorganisms. The studies are as mentioned below:

 

In the first study toxicity was measured on the basis of cell growth inhibition. Study was conducted to determine the effect of test chemical on the growth and cell proliferation of microorganisms Entosiphon sulcatum. Test conducted under the static system at 25° C. After the exposure of test chemical for 72 hrs, with microorganisms Entosiphon sulcatum, the LOEC was observed at 40 mg/l.

 

Similarly first study was supported by the second study from secondary source. Study was conducted to evaluate the effect of test chemical on the growth of microorganism Pseudomonas putida. Test conducted for 16 hrs. The low observed effect concentration (LOEC) value observed is 614 mg/l in Pseudomonas putida in a aquatic toxicity study conducted with test chemical on the basis of Cell Proliferation effect. On the basis of LOEC value it is concluded that the test chemical does not exhibit toxicity to microorganism (Pseudomonas putida).

 

Thus based on the above both studies chemical toxicity was observed as very low and the LOEC ranges from 40-614 mg/l.