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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
data is from RTECS

Data source

Referenceopen allclose all

Reference Type:
other: Authoritative database
Title:
Skin irritation study
Author:
IFA GESTIS
Year:
2018
Bibliographic source:
GESTIS Substance database (2018)
Reference Type:
secondary source
Title:
RTECS NUMBER : WB6475000
Author:
RTECS
Year:
2012
Bibliographic source:
RTECS, 2012

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Standard Draize test
Principles of method if other than guideline:
Standard Draize test was performed to determine the irritation potential of the test chemical
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium iodide
EC Number:
231-679-3
EC Name:
Sodium iodide
Cas Number:
7681-82-5
Molecular formula:
INa
IUPAC Name:
sodium iodide
Test material form:
solid: crystalline
Details on test material:
- Name of test material (as cited in study report): Sodium iodide- Molecular Formula: NaI- Molecular Weight: 149.89 g/mol- Substance type: Inorganic- Physical state: solid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
no data available

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
24hours
Observation period:
24hours
Number of animals:
no data available
Details on study design:
no data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Reversibility:
not specified
Remarks on result:
probability of moderate irritation
Irritant / corrosive response data:
Moderately irritating to rabbit skin

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
In a standard Draize test, the test chemical was moderately irritating to rabbit skin after 24 hours of exposure.
Executive summary:

A Standard Draize test was performed to determine the irritation potential of the test chemical in rabbits.

500 mg of the undiluted test chemical was applied to the rabbit skin and observed for signs of irritation till 24 hours.

The test chemical was moderately irritating to rabbit skin after 24 hours of exposure.