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Diss Factsheets

Toxicological information

Repeated dose toxicity: dermal

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Administrative data

Endpoint:
sub-chronic toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
WATER QUALITY CRITERIA FOR COLORED SMOKES: ) SOLVENT GREEN 3
Author:
Kowetha A. Davidson Patricia S. Hovatter
Year:
1987
Bibliographic source:
Chemical Effects Information Task Group Information Research and Analysis Section Health and Safety Research Division

Materials and methods

Principles of method if other than guideline:
13 weeks subchronic repeated dose toxicity study of 1,4-bis(p-tolylamino)anthraquinone (CI Solvent Green 3) in rabbit was conducted to evaluate adverse effects by dermal route.
GLP compliance:
not specified

Test material

1
Reference substance name:
1,4-bis(p-tolylamino)anthraquinone
EC Number:
204-909-5
EC Name:
1,4-bis(p-tolylamino)anthraquinone
Cas Number:
128-80-3
Molecular formula:
C28H22N2O2
IUPAC Name:
1,4-bis[(4-methylphenyl)amino]-9,10-anthraquinone

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
open
Vehicle:
other: petroleum or hydrophilic base
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
13 weeks
Frequency of treatment:
daily
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Results of examinations

Clinical signs:
no effects observed
Description (incidence and severity):
No significant local or systemic effects.
Dermal irritation:
not specified
Mortality:
no mortality observed
Description (incidence):
No significant local or systemic effects.
Body weight and weight changes:
not specified
Food consumption and compound intake (if feeding study):
not specified
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
not specified
Clinical biochemistry findings:
not specified
Urinalysis findings:
not specified
Behaviour (functional findings):
not specified
Organ weight findings including organ / body weight ratios:
not specified
Gross pathological findings:
not specified
Histopathological findings: non-neoplastic:
not specified
Histopathological findings: neoplastic:
not specified

Effect levels

Dose descriptor:
NOAEL
Effect level:
500 other: mg/kg
Based on:
test mat.
Sex:
not specified
Basis for effect level:
other: effects: did not cause significant local or systemic effects.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
In repeated dose toxicity study daily application of 500 mg/kg Solvent Green 3 in petroleum or hydrophilic base to skin of rabbit for 13 weeks did not cause significant local or systemic effects.
Thus the NOAEL for repeated dose toxicity by dermal route was considered to be 500 mg/kg.
Executive summary:

In repeated dose toxicity study daily application of 500 mg/kg Solvent Green 3 in petroleum or hydrophilic base to skin of rabbit for 13 weeks did not cause significant local or systemic effects.

Thus the NOAEL for repeated dose toxicity by dermal route was considered to be 500 mg/kg.