Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
other: company data
Title:
Acute inhalation study for Quino(2,3-b)acridine-7, l4-dione,5,12-dihydro
Author:
Haskell Laboratory
Year:
1983
Bibliographic source:
Haskell Laboratory, Medical Research Report Number 746-82, Project, No., MR-4368-001,

Materials and methods

Principles of method if other than guideline:
Acute inhalation toxicity of Pigment Violet 19 was assessed in CRL:CD rats.
GLP compliance:
not specified
Test type:
standard acute method

Test material

1
Reference substance name:
5,12-dihydroquino[2,3-b]acridine-7,14-dione
EC Number:
213-879-2
EC Name:
5,12-dihydroquino[2,3-b]acridine-7,14-dione
Cas Number:
1047-16-1
Molecular formula:
C20H12N2O2
IUPAC Name:
5,12-dihydroquino[2,3-b]acridine-7,14-dione

Test animals

Species:
rat
Strain:
other: CRL:CD
Sex:
male

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Concentrations:
1.5, 1.6, 2.4, 2.6 and 3.1 mg/I
No. of animals per sex per dose:
Groups of 6 rats
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
3.1 other: mg/L
Based on:
test mat.
Remarks on result:
other: Material would be considered as not toxic.
Mortality:
All rats survived
Clinical signs:
other: No significant clinical signs of toxicity observed.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The Acute inhalation LC50 value of 5,12-dihydroquino[2,3-b]acridine-7,14-dione (Pigment Violet 19) in Male CRL:CD rats was observed at dose concentration of >3.1 mg/m3.
Executive summary:

Toxicity of 5, 12-dihydroquino[2,3-b]acridine-7,14-dione (Pigment Violet 19) was assessed in CRL:CD rats. Pigment Violet 19 was given to Groups of 6 male rats via inhalation at dose concentrations of 1.5, 1.6, 2.4, 2.6 and 3.1 mg/I.

All rats survived, Other than transient weight losses there were no significant clinical signs of toxicity observed.

Thus it concluded that 5, 12-dihydroquino[2,3-b]acridine-7,14-dione (Pigment Violet 19) does not exhibit acute toxicity via the inhalation route i.e it is acutely non toxic to animals at the dose level >3.1 mg/I.