Decan-4-olide

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1995-07-19 to 1995-07-25

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

The study was conducted according to an internationally recognised method. No deviation affected the quality of the study. Purity of the test substance is specified. Therefore full validation applies.

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Version / remarks:

(1989)

Qualifier:

according to guideline

Guideline:

EU Method A.8 (Partition Coefficient)

Version / remarks:

(Directive 92/69/EEC)

GLP compliance:

yes

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

3

Temp.:

25 °C

Remarks on result:

other: pH not specified

Reference substances	Log Kow	tR1	tR2	mean tR	k	log k
Thiourea	---	1.35	1.35	1.35
Aniline	0.9	2.03	2.03	2.03	0.498	-0.302
Acetophenone	1.7	2.40	2.40	2.40	0.771	-0.113
Benzophenone	3.2	4.33	4.32	4.33	2.197	0.342
Naphtalene	3.6	5.24	5.23	5.23	2.866	0.457
1,2,4 -trichlorobenzene	4.2	8.44	8.42	8.43	5.226	0.718
n-butylbenzene	4.6	10.68	10.66	10.67	6.884	0.838
Triphenylamine	5.7	18.77	18.72	18.75	12.849	1.109

tR1, tR2: retention times (1st and 2nd calibration)

k = (tR/t0) -1: capacity factor

t0: dead time = retention time of thiourea

Linear regression parameters: log Kow = a x log k + b

a = 3.264

b = 1.993

r² = 0.995

Test substance:

tR1 = 4.177

tR2 = 4.175

mean tR = 4.176

k = 2.085

log k = 0.319

log Kow = 3.0

Conclusions:

The substance should have low to medium potential for bioaccumulation.
The result hardly reaches the cut-off value for classication in aquatic chronic toxicity, according to Directive 67/548/EEC (DSD) criteria, and is below the threshold according to Regulation (EC) No.1272/2008 (CLP).

Executive summary:

According to OECD/EC HPLC method, a partition coefficient Log Kow of 3.0 was measured for the substance.

Description of key information

The substance should have low to medium potential for bioaccumulation.

The result hardly reaches the cut-off value for classication in aquatic chronic toxicity, according to Directive 67/548/EEC (DSD) criteria, and is below the threshold according to Regulation (EC) No.1272/2008 (CLP).

Key value for chemical safety assessment

Log Kow (Log Pow):

3

at the temperature of:

25 °C

Additional information

A reliable study, conducted according to the OECD guideline, is available. Therefore, it is considered as a key study, and the result is retained for purpose of CSA.