Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Short description of key information on bioaccumulation potential result: 
The substance is expected to be stable under the conditions of stomach and duodenum and to pass the intestines unchanged and to be excreted directly via faeces.  A bioaccumulation of the test item is considered unlikely, because the substance is poorly absorbed and offers hydroxy groups for phase II xenobiotoc metabolism.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

Functional groups relevant for hydrolysis

The substance contains ether and ester bonds. Both are generally stable with regard to pH-dependent hydrolysis at pH values present in the gastrointestinal tract. Ester bonds may undergo enzymatic cleavage, provided that the substance is taken up into cells.

Functional groups relevant for elimination

The route of excretion is assumed to be via the biles using the glucuronic acid-conjugate pathway. Glucuronic acid conjugates are most likely formed either with the phenolic -OH groups, or with secondary carboxylic acids formed in the course of the metabolism along the aliphatic side chain. It is considered rather unlikely, that water-soluble metabolites would be formed by oxidation along the sidechain and sulfation on the phenolic -OH. Glucuronidated metabolites are generally known to be rapidly excreted.

Indication of uptake

In the intestines, due to its very low solubility in water and the large molecular weight only a small amount of the article is expected to be absorbed. Almost the entire ingested test item is expected to pass the intestines unchanged and to be excreted directly via faeces. With respect to the very small part of the substance resorbed, most is expected to become directly glucuronidated in the liver and excreted via the bile. This is likely as the substance has free phenolic hydroxy groups.

In the subacute toxicity study fatty changes in liver and adrenal glands of the treated rats have been observed. These effects are physiological responses to biochemical processes and stress and indicate that a certain amount of the test article is bioavailable.

Evaluation of the bioaccumulation potential

A bioaccumulation potential is unlikely because the substance is probably poorly absorbed and offers hydroxy groups for phase II xenobiotoc metabolism.