Registration Dossier
Registration Dossier
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EC number: 469-110-8 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Skin and eye irritation of AD-1000 was tested according to current test guidelines and AD-1000 was not irritating for both skin and eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin
In a study performed according to OECD 404, EC B.4, EPA and JMAFF guidelines, rabbits were exposed to 0.5 g of AD-1000 moistened with watery ethanol by application onto clipped skin for 4 hours using a semi-occlusive dressing. Skin reactions were assessed 1, 24, 48, and 72 hours after exposure. No skin irritation was observed. No symptoms of systemic toxicity were observed in the animals during the test period and no mortality occurred.
Eye
In a study performed according to OECD 405, EC B.5, EPA and JMAFF guidelines, AD-1000 was instilled into one eye of each of the rabbits. Observations were made 1, 24, 48 and 72 hours after instillation. Instillation resulted in irritation of the conjunctivae, which consisted of redness in one animal, and redness and discharge in two other animals. the irritation had completely resolved within 24 hours in the first animal and 38 hours in the latter two animals. AD-1000 is not considered to be an eye irritant. No symptoms of systemic toxicity were observed in the animals during the test period and no mortality occurred.
Justification for classification or non-classification
Based on the studies present, AD-1000 does not have to be classified according to 67/548/EEC and the CLP Regulation (EC) No 1272/2008 for skin or eye irritation.
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