Reaction mass of N, N'-hexane-1,6-diylbis [12-hydroxyoctadecanamide] and 12-hydroxy-N-[6-[1-oxoalkyl)amino] hexyl ] octadecanamide

Bioaccumulation: aquatic / sediment

Administrative data

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

This analogue substance was found through a quick and dirty search on similarity using the OECD QSAR toolbox. Estimated logPow values via KOWWIN v1.67 (EPIWEB 4.0) show very similar values above 10. Furthermore, physicochemical properties like melting point, boiling point and water solubility are very similar. Based on the points above and the fact that this analogue is probably worst case for bioconcentration than the registered substance (lower MW and therefore an expected higher bioavailability), it is deemed appropriate to use the bioconcentration data of this analogue to evaluate the bioaccumulation potential of the registered substance.

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Bioconcentration test - unspecified

Deviations:

not specified

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
IUCLID data set ESIS:
- Melting point ca 140 ºC (unspecified method)
- Boiling point > 200 ºC or > 300 ºC (unspecified method)
- Insoluble in water (unspecified method)
- density ca 0.94 (unspecified method)

QSAR KOWWIN v1.67: logKow = 13.98
QSAR BCFBAF v3.00: estimated BCF = 5.048 L/kg wwt

Test organisms

Test organisms (species):

Cyprinus carpio

Details on test organisms:

Lipid content 3.9%

Test conditions

Details on test conditions:

Test period: 6 weeks
Standard type test equipment
Two concentration sets: 0.083 mg/L and 0.830 mg/L

Results and discussion

Lipid content

Lipid content:

3.9 %

Time point:

other: no information

Bioaccumulation factor

Bioaccumulation factor 1

Type:

BCF

Value:

< 6.2

Basis:

not specified

Remarks on result:

other: Conc.in environment / dose:0.083 mg/L

Bioaccumulation factor 2

Type:

BCF

Value:

< 0.7

Basis:

not specified

Remarks on result:

other: Conc.in environment / dose:0.830 mg/L

Any other information on results incl. tables

The data of physico-chemical properties like melting point, boiling point, density and water solubility were compared between the analogue and the registered substance. All values were very similar.

The estimated logPow value via KOWWIN v1.67 (EPIWEB 4.0) of the analogue is 13.98. This value is very similar to the estimation for the registered substance (13.28) and both can be deemed to be higher than 10.

The estimated value of BCF via BCFBAF v3.00 of the analogue was very comparable with the estimated value of the registered substance (see 5.3.1 QSAR).

Based on the points above and the fact that this analogue is probably worst case for bioconcentration than the registered substance (lower MW and thus expected higher bioavailability), it is deemed appropriate to use the bioconcentration data of this analogue to evaluate the bioaccumulation potential of the registered substance.