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EC number: 224-226-6 | CAS number: 4253-90-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Di-tert-butyl trisulphide
- EC Number:
- 224-226-6
- EC Name:
- Di-tert-butyl trisulphide
- Cas Number:
- 4253-90-1
- Molecular formula:
- C8H18S3
- IUPAC Name:
- di-tert-butyltrisulfane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Iffa Créco (69210 L'Arbresle, France)
- Age at study initiation: 8-week old
- Weight at study initiation: 270 +/- 10 g for males and 215 +/- 9 g for females
- Fasting period before study: not appropriate
- Housing: polycarbonate cages
- Diet (e.g. ad libitum): AO4C (UAR, 91360 Villemoisson/Orge, France)
- Water (e.g. ad libitum): filtered tap water
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3
- Humidity (%): 50 +/- 20
- Air changes (per hr): 13
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The test substance was administered by dermal route to a group of 10 Sprague-Dawley rats (5 males and 5 females). The test substance in its original form was applied directly to the skin at a dose of 2000 mg/kg, taking into consideration that the specific gravity (SG) of the test substance was 1.007. After 24 hours under a semi-occlusive dressing, no residual test substance was observed on removal of the dressing.
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- The animals were checked for clinical signs, mortality and body weight gain for a period of 14 days following the single application of the test substance. A necropsy was performed on each animal sacrificed at the end of the study.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Remarks on result:
- other: No mortality, clinical sign and cutaneous reaction
- Mortality:
- No deaths occurred at 2000 mg/kg
- Clinical signs:
- other: The general behaviour of the animals was not affected by treatment with the test substance. No cutaneous reactions were observed.
- Gross pathology:
- A macroscopic examination revealed no abnormalities in the animals sacrificed at the end of the study.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD0 of TPS 44, when administered by dermal route in rats was 2000 mg/kg. No signs of toxicity were observed at this dose.
- Executive summary:
The acute toxicity of TPS 44, by dermal route was evaluated in rats according to O.E.C.D. (No. 402, 24th February 1987) guidelines. The study was conducted in compliance with the Principles of Good Laboratory Practice.
TPS 44 was administered by dermal route to a group of 10 Sprague-Dawley rats (5 males and 5 females). TPS 44 in its original form was applied directly to the skin at a dose of 2000 mg/kg, taking into consideration a specific gravity (SG) of 1.007. After 24 hours under a semi-occlusive dressing, no residual test substance was observed on removal of the dressing. The animals were checked for clinical signs, mortality and body weight gain for a period of 14 days following the single application of the test substance.
A necropsy was performed on each animal sacrificed at the end of the study.
The general behaviour and body weight gain of the animals were not affected by treatment with the test substance. No deaths occurred at 2000 mg/kg. A macroscopic examination revealed no abnormalities in the animals sacrificed at the end of the study.
The LDo of TPS 44, when administered by dermal route in rats was 2000 mg/kg. No signs of toxicity were observed at this dose.
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