Registration Dossier
Registration Dossier
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EC number: 448-060-0 | CAS number: 727678-39-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (96 h) > 0.043 mg/L (measured concentration). No effects up to the limit of water solubility (0.04 mg/L) (OECD 203).
Key value for chemical safety assessment
Additional information
The acute toxicity of 2-[2-(3-butoxypropyl)-1,1-dioxo-1,2,4-benzothiadiazin-3yl]-5'-tert-butyl-2-(5,5-dimethyl-2,4-dioxo- 1,3-oxazolidin-3-yl)-2'-[(2-ethylhexyl)thio]acetanilide (UY-330) to fish was determined in a study by Bouwman (2004). This test was conducted according to ISO 7346-1, EU Method C.1 and OECD Guideline 203 under GLP conditions. During the study, two limit tests were performed under static conditions. Common carp (Cyprinus carpio) were exposed for 96 hours to a filtered solution prepared at 100 mg/L nominal (verification of test concentration was performed by HPLC analysis). No mortality or other adverse effects could be observed at the end of the exposure period. Therefore, a LC50 value could not be calculated and it is considered to be > 0.043 mg/L (measured concentration).
In conclusion, UY-330 was considered to be not acute toxic to fish under the tested conditions. No effects of the substance are expected in the range of the water solubility of the test substance (0.04 mg/L). Thus, in addition a LC50 > 100 mg/L based on the nominal test concentration of the test substance in a filtered solution is assumed and reported in the study summary.
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