Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation: in vitro
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
QSAR Toolbox prediction for single chemical
Year:
2021
Bibliographic source:
QSAR Toolbox 3.4.0.17

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: QSAR Toolbox 3.4.0.17
Version / remarks:
Database version: 3.8.8/3.1.2
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
(4R)-4-[(4S)-2-oxo-1,3-dioxolan-4-yl]-1,3-dioxolan-2-one
EC Number:
636-728-6
Cas Number:
24690-44-6
Molecular formula:
C6H6O6
IUPAC Name:
(4R)-4-[(4S)-2-oxo-1,3-dioxolan-4-yl]-1,3-dioxolan-2-one
Test material form:
solid

Results and discussion

In vitro / in chemico

Results
Run / experiment:
other: QSAR
Parameter:
other: Skin sensitisation II (ECETOC)
Vehicle controls validity:
not applicable
Negative controls validity:
not applicable
Positive controls validity:
not applicable
Remarks on result:
no indication of skin sensitisation
Other effects / acceptance of results:
The prediction is based on 5 neighbours' values, 3 of them equal to prediction.
Prediction confidence is measured by the p-value = 0.500 (no confidence)

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met