(2S-cis)-(diphenylmethyl)-N-(phenylmethyl)-1-azabicyclo[2.2.2.]octan-3-amine (1-R camphor-10-sulfonate)

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From 23rd of July 1998 to 28th of July 1998.

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1999

Report date:

1999

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

other: EEc method No. A.6

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

444-810-6

EC Name:

-

Molecular formula:

C27 H30 N2 * C10 H16 O4 S

IUPAC Name:

(2S-cis)-(diphenylmethyl)-N-(phenylmethyl)-1-azabicyclo[2.2.2.]octan-3-amine (1-R camphor-10-sulfonate)

Test material form:

solid: particulate/powder

Results and discussion

Water solubility

Key result

Water solubility:

ca. 4.43 g/L

Loading of aqueous phase:

500 other: mg in 25 ml purified water

Temp.:

20 °C

pH:

>= 6.15 - <= 6.43

Details on results:

No peaks were observed in the chromatograms of the blank solutions indicating that the analytical
method was free from interference.

Applicant's summary and conclusion

Conclusions:

The water solubility of CP-163,625-BV was found to be 4.43 g/l.

Executive summary:

The water solubility of CP-163,625-BV was found to be 4.43 g/l.