Registration Dossier
Registration Dossier
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EC number: 444-810-6 | CAS number: -
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 September 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- other: EC Method A.8
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- -
- EC Number:
- 444-810-6
- EC Name:
- -
- Molecular formula:
- C27 H30 N2 * C10 H16 O4 S
- IUPAC Name:
- (2S-cis)-(diphenylmethyl)-N-(phenylmethyl)-1-azabicyclo[2.2.2.]octan-3-amine (1-R camphor-10-sulfonate)
- Test material form:
- solid: particulate/powder
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- ca. 5.2
- Remarks on result:
- other: Temperature
- Remarks:
- Temperature was not recorded.
- Details on results:
- From the primary data a calibration curve was generated.
The mean calibration curve was used to interpolate the results.
The mean calibration curve produced was:
logio Pow = 3.12 log iok + 1.95
Where k = capacity factor
k = t'r/to = (tr-to)/to
and t', = true retention time obtained by subtracting deadtime, or to, of I.D.S. from measured
retention time of sample or reference.
A log Pow, value of 5.2 was thus obtained for CP-163,625-BV.
Applicant's summary and conclusion
- Conclusions:
- CP-163,625-BV was determined to have a log Pow value of 5.2
- Executive summary:
CP-163,625-BV was determined to have a log Pow value of 5.2
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