(2S-cis)-(diphenylmethyl)-N-(phenylmethyl)-1-azabicyclo[2.2.2.]octan-3-amine (1-R camphor-10-sulfonate)

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

The experimental phase of the study was undertaken between 8 June 1998 and 14 September 1998.

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1999

Report date:

1999

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

Principles of Good Laboratory Practice (as revised in 1997),
ENV/MC/CHEM(98)17.

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

other: EEC Method A.1 (Melting Temperature)

Version / remarks:

EC Council Directive 87/18/EEC of 18 December 1986 (Official Journal No L 15/29).

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

other: Metal block method.

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

444-810-6

EC Name:

-

Molecular formula:

C27 H30 N2 * C10 H16 O4 S

IUPAC Name:

(2S-cis)-(diphenylmethyl)-N-(phenylmethyl)-1-azabicyclo[2.2.2.]octan-3-amine (1-R camphor-10-sulfonate)

Test material form:

solid: particulate/powder

Results and discussion

Melting / freezing point

Key result

Atm. press.:

ca. 101 325 Pa

Decomposition:

yes

Decomp. temp.:

ca. 200 °C

Any other information on results incl. tables

Using a Mettler-Toledo Model DSC12E Differential Scanning Calorimeter, CP-163,625-BV was shown to soften from 46 to 195°C as indicated by a very broad endotherm, and then to decompose at temperatures above 200°C as shown by a sharp exotherm. Decomposition was immediately followed by an endotherm, indicating melting of decomposition products.

Applicant's summary and conclusion

Conclusions:

CP-163,625-BV was found to decompose above 200°C before melting.

Executive summary:

CP-163,625-BV decomposes before melting above 200°C, melting point can't be determined.