Registration Dossier
Registration Dossier
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EC number: 247-161-5 | CAS number: 25646-71-3
Endpoint summary
Administrative data
Description of key information
In an occupational exposure investigation for the period from January 1980 to June 1981, employees working at a cinematographic film laboratory were given a questionnaire and a clinical examination for those who stated that they had skin disease (Liden, 1984). Patch testing also was conducted for all those cases with suspected dermal occupational dermatoses. Questionnaires were given to 114 workers. From those 114 workers, 103 answered the questionnaire, with 41 of them stating that they were exposed to chemicals, including CD-3, at work. In for cases, contact allergy was found to the photographic chemical CD-3. The color developing agent might also have given rise to lichenoid reactions and 2 such cases were seen in this investigation. Other causes of occupational dermatoses were indicated, as well as the occurrence of non-occupational skin diseases.
A follow-up investigation was conducted since in 1983 the film laboratory moved to new premises built to reduce exposure to hazardous chemicals. Therefore, the period from 1983 to 1986 was investigated, with repeated interviews and dermatological examinations of all employees (78 subjects) and patch testing those with a history of or with current chemical exposure or dermatitis (65 subjects). Of these 65 subjects, 2 showed a positive response to CD-3. Based on the results of the study, the authors concluded that the occurrence and severity of occupational dermatoses were reduced by the technical measures taken to reduce chemical exposure.
In a study the clinical picture, course and patch test results of 24 patients with occupational skin disease caused by colour developing agents, including CD-3 were described (Liden and Brehmer-Andersson, 1988). Biopsies for histopathology of the occupationally-induced lesions and/or patch test reactions were obtained in 14 cases. Contact allergy to color developing agents, including CD-3, was found in 23 cases. The clinical and histopathological findings showed that lichen planus and lichen planus-like lesions were common among the dermatoses caused by color developers. It was not possible to provoke lichenoid lesions by patch testing. The histopathology of the patch test reactions showed dermatitis.
Additional information
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