Registration Dossier
Registration Dossier
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EC number: 938-572-7 | CAS number: -
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1994-1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
- Objective of study:
- absorption
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The aim of this study was to investigate the absorption of TMP in an in vitro study using everted rat intestinal sacs.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-ethyl-2-(methoxymethyl)propane-1,3-diol
- EC Number:
- 231-621-7
- EC Name:
- 2-ethyl-2-(methoxymethyl)propane-1,3-diol
- Cas Number:
- 7658-03-9
- Molecular formula:
- C7H16O3
- IUPAC Name:
- 2-ethyl-2-(methoxymethyl)propane-1,3-diol
- Reference substance name:
- 2-ethylpropane-1,3-diol
- EC Number:
- 220-038-3
- EC Name:
- 2-ethylpropane-1,3-diol
- Cas Number:
- 2612-29-5
- Molecular formula:
- C5H12O2
- IUPAC Name:
- 2-ethylpropane-1,3-diol
- Test material form:
- liquid
Constituent 1
Constituent 2
- Radiolabelling:
- no
Test animals
- Species:
- other: in vitro
Results and discussion
Any other information on results incl. tables
Calculated amount of DMP absorbed into serosal fluid
Sample |
Calculated amount of DMP absorbed into serosal fluid (µmoles) |
Mean (µmoles) |
±SD |
|
|
|
|
Serosal fluid 1 Rat 1 |
15.995 |
|
|
Serosal fluid 2 Rat 1 |
13.780 |
|
|
Serosal fluid 3 Rat 1 |
13.992 |
14.589 |
1.222 |
|
|
|
|
Serosal fluid 1 Rat 2 |
15.271 |
|
|
Serosal fluid 2 Rat 2 |
15.094 |
|
|
Serosal fluid 3 Rat 2 |
16.922 |
15.762 |
1.008 |
|
|
|
|
External media 60 min |
19.551 |
|
|
Original concentrations of 20µmoles/400µL (Total incubation volume of 10mL)
Applicant's summary and conclusion
- Conclusions:
- From these results it can be concluded that DMP was extensively absorbed into the intestinal sacs.
- Executive summary:
The absorption of DMP was investigated in vitro using an everted rat gut sac model. The results of the study indicate that DMP was extensively absorbed into the intestinal sacs.
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