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EC number: 938-572-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- The test fish were received in November 2008 from import quarantine and were kept in internal quarantine for 14 days before the start of the study.
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- No
- Hardness:
- 250±25 mg/L calcium carbonate
- Test temperature:
- 24±1°C
- pH:
- 7.8±0.2
- Dissolved oxygen:
- >90% saturation
- Salinity:
- Not applicable
- Conductivity:
- Not applicable
- Nominal and measured concentrations:
- Nominal exposure concentrations: 0 (control), 400, 800, 1600, 3200 and 6400 mg/L.
- Details on test conditions:
- Fish were incubated under semi-static conditions with exchange of test and control solutions every 24 hours.
Dilution water was aerated ot oxygen saturation exceeding 90% with a pH of 7.8 +- 0.2. This fish were tested in 5L glass vessels. With normal laboratory illumination and a light dary cycle of 16:8. The following loading rates were used with 7 fish per rate: 0 (control), 400, 800, 1600, 3200, 6400 mg/L nominal. - Reference substance (positive control):
- yes
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 2 400 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 800 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- behaviour
- Details on results:
- Mortality after 96 hours exposure was 0% in the control, 400, 800 and 1600 mg/L, 100% mortality was observed at 3200 and 6400 mg/L. Visible abnormalities (eg darker pigmentation, loss of equilibrium, disturbance in swimming behaviour or increased respiration rate) were observed in all fish at the nomi9nal 1600 mg/L concentration.
- Results with reference substance (positive control):
- Disodium heptachromate was used a reference material. The 24 h LC50 fulfilled the acceptance criterion of 200 - 400 mg/L.
- Reported statistics and error estimates:
- Not applicable
- Sublethal observations / clinical signs:
The test substance demonstrated low toxicity to fish in this acute study. The nominal 96 hour LC50 was found to be 2400 mg/L with a NOEC of 800 mg/L.
- Validity criteria fulfilled:
- yes
- Conclusions:
- 96 hour LC50 was found to be 2400 mg/L
- Executive summary:
In a 96-h acute toxicity study, zebrafish (Danio rerio) were exposed to DMP-Tech (Reaction mass of 2-ethyl-2-(methoxymethyl)-propane-1,3-diol and 2-ethylpropane-1,3-diol) at nominal concentrations of 0 (control), 400, 800, 1600, 3200 and 6400 mg/L under semi-static conditions. The 96-h LC50 was 2400 mg/L. The NOEC value based on behavioural differences was observed to be 800 mg/L. Sublethal effects of visible abnormalities (e.g. darker pigmentation, loss of equilibrium, disturbance in swimming behaviour or increased respiration rate) were observed in the groups exposed to 1600 mg/L of DMP-Tech. Based on the results of this study, DMP-Tech would be classified as not hazardous to the aquatic environment in accordance with the classification system of the U.S. EPA.
This toxicity study is classified as acceptable and satisfies the guideline requirement for short-term toxicity study to fish.
Reference
Description of key information
In an OECD 203 study the 96-hour LC50 was determined to be 2400 mg/L, and the NOEC 800 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 2 400 mg/L
Additional information
A semi-static GLP study to OECD 203 was carried out to determine the toxicity to fish. The test substance demonstrated low toxicity to fish in this acute study. The nominal 96 hour LC50 was found to be 2400 mg/L with a NOEC of 800 mg/L. The test substance should be considered non toxic to fish.
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