Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-207-0 | CAS number: 79-43-6
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Route is not applicable.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 979
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dichloroacetic acid
- EC Number:
- 201-207-0
- EC Name:
- Dichloroacetic acid
- Cas Number:
- 79-43-6
- Molecular formula:
- C2H2Cl2O2
- IUPAC Name:
- 2,2-dichloroacetic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Duration of treatment / exposure:
- 38 d
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0–250 mg/kg bw
Results and discussion
Results of examinations
- Details on results:
- No relevant toxicological effects observed.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Dichloroacetate has been given intravenously to rats (up to 250 mg per kilogram for 38 days) without demonstrable adverse effects.
- Executive summary:
It should be noted that, in contrast to the toxicity associated with its chronic, oral administration, dichloroacetate has been given intravenously to rats (up to 250 mg per kilogram for 38 days) without demonstrable adverse effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
