Registration Dossier
Registration Dossier
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EC number: 201-207-0 | CAS number: 79-43-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1951
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Publication supporting the waiving arguments.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 951
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- Dichloroacetic acid
- EC Number:
- 201-207-0
- EC Name:
- Dichloroacetic acid
- Cas Number:
- 79-43-6
- Molecular formula:
- C2H2Cl2O2
- IUPAC Name:
- 2,2-dichloroacetic acid
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
Results and discussion
In vivo
Results
- Remarks on result:
- other: Primary skin irritation on rabbits was 7/10.
- Remarks:
- no details reported
- Irritant / corrosive response data:
- slightly irritating
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information
- Conclusions:
- The grade of primary irritation hazard given is explained by Smyth, Carpenter and Weil. Primary skin irritation on rabbits was 7/10.
- Executive summary:
Primary skin irritation grade on rabbits was 7/10 in a skin irritation and corrosion study in rabbits.
Therefore most conservatie classification as skin corrosive is proposed and further testing is avoided.
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