Potassium benzoate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size

Justification for type of information:

The substance has a low dust content and very low vapour pressure

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Justification for type of information:

Performed using claibrated specialist equipment

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)

Principles of method if other than guideline:

Using Bettersize instruments, optical analysis.
Dispersed in sunflower oil

GLP compliance:

no

Type of method:

Laser scattering/diffraction

Type of particle tested:

primary particle

Type of distribution:

mass based distribution

Mass median aerodynamic diameter:

ca. 15.8 µm

Key result

Percentile:

D50

Mean:

ca. 15.8 µm

Percentile:

D10

Mean:

ca. 4.45 µm

Approximately 30% < 10 µm

Conclusions:

This sample of fine particles has approximately 30% < 10 µm, but the D10 was 4. 45, suggesting a relatively low dust content.
Different batches and different sources will have different particle size distributions.