2-aminothiazol-4-acetic acid

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2011

Report date:

2011

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

ISO 6341 (Water quality - Determination of the Inhibition of the Mobility of Daphnia magna Straus (Cladocera, Crustacea))

Version / remarks:

Method 6.1: 1996/Cor.1:1998

Deviations:

not specified

GLP compliance:

not specified

Remarks:

likely to be GLP but not specified in data available

Test material

Test material information

Constituent 1

Reference substance name:

2-aminothiazol-4-acetic acid

EC Number:

249-769-6

EC Name:

2-aminothiazol-4-acetic acid

Cas Number:

29676-71-9

Molecular formula:

C5H6N2O2S

IUPAC Name:

(2-amino-1,3-thiazol-4-yl)acetic acid

Test material form:

solid: particulate/powder

Sampling and analysis

Analytical monitoring:

not specified

Test solutions

Vehicle:

not specified

Details on test solutions:

No information is provided on how test solutions were prepared.

Test organisms

Test organisms (species):

Daphnia magna

Details on test organisms:

No details available on source and use of Daphnia magna. Assumed neonates used were less than 24 hours old in accordance with the followed guidance.

Study design

Test type:

not specified

Water media type:

not specified

Limit test:

no

Total exposure duration:

48 h

Test conditions

Test temperature:

20.7°C

pH:

6.0

Dissolved oxygen:

12.7 mg/L

Salinity:

< 1 ppt at 20°C

Conductivity:

560 µS/cm at 25°C

Nominal and measured concentrations:

Nominal Concentrations of 100, 180 and 320 mg/L are detailed.

Details on test conditions:

No detailed information on experimental conditions available.

Reference substance (positive control):

not specified

Results and discussion

Effect concentrations

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

138 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Details on results:

Immobilisation results:

100 mg/L: No Daphnia immobilised.
180 mg/L: 95% of Daphnia immobilised.
320 mg/L: 100% of Daphnia immobilised.

Results with reference substance (positive control):

Not specified

Reported statistics and error estimates:

95% confidence limits of 130.5 to 146.2 (% vol/vol) calculated using Trimmed Spearman-Karber.

Applicant's summary and conclusion

Validity criteria fulfilled:

not specified

Conclusions:

Under the conditions of the test conducted in accordance with ISO guidance provides a 48 hr EC50 value of 138 mg/L to Daphnia magna.