Registration Dossier
Registration Dossier
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EC number: 249-769-6 | CAS number: 29676-71-9
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 2-aminothiazol-4-acetic acid
- EC Number:
- 249-769-6
- EC Name:
- 2-aminothiazol-4-acetic acid
- Cas Number:
- 29676-71-9
- Molecular formula:
- C5H6N2O2S
- IUPAC Name:
- (2-amino-1,3-thiazol-4-yl)acetic acid
- Test material form:
- solid: particulate/powder
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- -2.13
- Temp.:
- 20 °C
- pH:
- >= 4.54 - <= 4.64
- Remarks on result:
- other: Exact temperature not specfied (between 20 and 25°C).
- Details on results:
- Octanol/water ratios of 1:1, 2:1, and 1:2 were used in the determination.
Applicant's summary and conclusion
- Conclusions:
- The Log Pow of the test substance was determined using a shake-flask method to be -2.13.
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