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Long-term toxicity to aquatic invertebrates

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Description of key information

Chronic effects on aquatic invertebrates are not expected.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
4 mg/L

Additional information

To determine chronic effects of 4,4'-methylenebis(2-methylcyclohexanamine) (CAS 6864 -37 -5, DMDC) on aquatic invertebrates, a GLP-study according to OECD 211 (21 d-reproduction test) was performed with Daphnia magna. The test concentrations were analytically verified. The mean measured concentrations for the whole exposure period were within ±20% of the nominal concentration. The NOEC was determined to be 4.0 mg/L (reproduction; nominal) (NITE Japan, 2003; NMMP/E00/3090). All validity criteria were fulfilled in this study. Based on the NOEC of 4.0 mg/L chronic effects on aquatic invertebrates are not expected.