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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
This study was conducted in 1970.
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Abstract only

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1970
Report date:
1970

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The test substance was administered to the eyes of rabbits for 24 hours at a range of concentrations (3 - 50 %) and observations were made for seven days.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2,3,4,4a,7,8,8a-octahydro-2,4a,5,8a-tetramethyl-1-naphthyl formate
EC Number:
265-742-1
EC Name:
1,2,3,4,4a,7,8,8a-octahydro-2,4a,5,8a-tetramethyl-1-naphthyl formate
Cas Number:
65405-72-3
Molecular formula:
C15H24O2
IUPAC Name:
1,2,3,4,4a,7,8,8a-octahydro-2,4a,5,8a-tetramethyl-1-naphthyl formate
Test material form:
liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
3 %, 10 %, 30 % and 50 %.
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
Seven days
Number of animals or in vitro replicates:
No data
Details on study design:
No data

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
chemosis score
Basis:
mean
Time point:
24 h
Score:
1
Max. score:
4
Reversibility:
fully reversible within: 4 days
Irritation parameter:
chemosis score
Basis:
mean
Time point:
48 h
Score:
1
Max. score:
4
Reversibility:
fully reversible within: 4 days
Irritation parameter:
chemosis score
Basis:
mean
Time point:
72 h
Score:
1
Max. score:
4
Reversibility:
fully reversible within: 4 days

Any other information on results incl. tables

Irritation score

Concentration

Reactions, days following application

1

2

3

4

5

6

7

3 %

-

-

-

-

-

-

-

10 %

(+)

-

-

-

-

-

-

30 %

(+)

-

-

-

-

-

-

50 %

+

(+)

(+)

-

-

-

-

- = No redness

(+) = weak redness

+ = moderate redness and secretion

++ strong redness and strong secretion

+++ strong redness and strong secretion with oedema

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The test substance was administered to the eyes of rabbits for 24 hours at a range of concentrations (3 - 50 %). Observations indicated weak to moderate redness of the conjunctiva, which was reversed within a maximum of four days.
Executive summary:

The test substance was administered to the eyes of rabbits for 24 hours at a range of concentrations (3 - 50 %). Observations indicated weak to moderate redness of the conjunctiva, which was reversed within a maximum of four days.