1,2,3,4,4a,7,8,8a-octahydro-2,4a,5,8a-tetramethyl-1-naphthyl formate

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

This study was conducted in 1970.

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Abstract only

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1970

Report date:

1970

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The test substance was administered to the eyes of rabbits for 24 hours at a range of concentrations (3 - 50 %) and observations were made for seven days.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

1,2,3,4,4a,7,8,8a-octahydro-2,4a,5,8a-tetramethyl-1-naphthyl formate

EC Number:

265-742-1

EC Name:

1,2,3,4,4a,7,8,8a-octahydro-2,4a,5,8a-tetramethyl-1-naphthyl formate

Cas Number:

65405-72-3

Molecular formula:

C15H24O2

IUPAC Name:

1,2,3,4,4a,7,8,8a-octahydro-2,4a,5,8a-tetramethyl-1-naphthyl formate

Test material form:

liquid

Test animals / tissue source

Species:

rabbit

Strain:

not specified

Details on test animals or tissues and environmental conditions:

No data

Test system

Vehicle:

not specified

Controls:

not specified

Amount / concentration applied:

3 %, 10 %, 30 % and 50 %.

Duration of treatment / exposure:

24 hours

Observation period (in vivo):

Seven days

Number of animals or in vitro replicates:

No data

Details on study design:

No data

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

chemosis score

Basis:

mean

Time point:

24 h

Score:

1

Max. score:

4

Reversibility:

fully reversible within: 4 days

Results 2

Irritation parameter:

chemosis score

Basis:

mean

Time point:

48 h

Score:

1

Max. score:

4

Reversibility:

fully reversible within: 4 days

Results 3

Irritation parameter:

chemosis score

Basis:

mean

Time point:

72 h

Score:

1

Max. score:

4

Reversibility:

fully reversible within: 4 days

Any other information on results incl. tables

Irritation score

Concentration	Reactions, days following application
	1	2	3	4	5	6	7
3 %	-	-	-	-	-	-	-
10 %	(+)	-	-	-	-	-	-
30 %	(+)	-	-	-	-	-	-
50 %	+	(+)	(+)	-	-	-	-

- = No redness

(+) = weak redness

+ = moderate redness and secretion

++ strong redness and strong secretion

+++ strong redness and strong secretion with oedema

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The test substance was administered to the eyes of rabbits for 24 hours at a range of concentrations (3 - 50 %). Observations indicated weak to moderate redness of the conjunctiva, which was reversed within a maximum of four days.

Executive summary:

The test substance was administered to the eyes of rabbits for 24 hours at a range of concentrations (3 - 50 %). Observations indicated weak to moderate redness of the conjunctiva, which was reversed within a maximum of four days.