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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
The study was conducted in 1978.
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
A single application of the test material was added to 2 cm2 of clipped skin on the flank of a guinea pig. Skin reactions were noted at 24 hours.
GLP compliance:
no
Remarks:
Study pre-dates GLP.

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2,3,4,4a,7,8,8a-octahydro-2,4a,5,8a-tetramethyl-1-naphthyl formate
EC Number:
265-742-1
EC Name:
1,2,3,4,4a,7,8,8a-octahydro-2,4a,5,8a-tetramethyl-1-naphthyl formate
Cas Number:
65405-72-3
Molecular formula:
C15H24O2
IUPAC Name:
1,2,3,4,4a,7,8,8a-octahydro-2,4a,5,8a-tetramethyl-1-naphthyl formate
Test material form:
liquid

Test animals

Species:
guinea pig
Strain:
not specified
Details on test animals or test system and environmental conditions:
No data

Test system

Type of coverage:
open
Preparation of test site:
clipped
Vehicle:
other: Acetone
Controls:
no
Amount / concentration applied:
0.025 mL at concentrations of 3, 10, 30 and 100 %
Duration of treatment / exposure:
24 hours
Observation period:
24 hours
Number of animals:
No data
Details on study design:
A single application of 0.025 mL of each test concentration was simultaneously performed on an area measuring 2 cm2 of the flank of skin previously clipped and marked with a circular stamp.
The skin reactions were read 24 hours after application of the test material. The minimum and maximum non-irritant concentrations were determined by an all-or-none criterion. The minimal irritant concentration was defined as the lowest one causing skin irritation. The maximal non-irritant concentration was defined as the highest one not causing macroscopic skin irritation in any of the animals.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: Lowest irritant concentration
Basis:
other: No data
Time point:
other: 24 h
Score:
10
Reversibility:
no data
Irritation parameter:
other: Highest non-irritant concentration
Basis:
other: No data
Time point:
other: 24 h
Score:
3
Reversibility:
no data

Any other information on results incl. tables

Skin irritation after a single application

Solvent

Lowest irritant concentration

Highest non-irritant concentration

Acetone

10 %

3 %

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
After a single application of the test substance, a 3% concentration in acetone does not cause skin irritation. Application of 10 % in acetone caused irritation.
After 7 days continuous application of the test item, only mild irritation was observed.
Executive summary:

The skin irritation potential of the test substance was assessed in guinea pigs.

After a single application of the test substance a 3% concentration in acetone did not irritate the skin.

A 10 % concentration was the lowest irritant concentration after a single application of the test substance.

This non-classification is based on the additional information after 21 days repeated dosing at 3%, 10%, 30% and 100% where after 7 days dosing at 100%, only slight irritation was observed.

Therefore after a single dose, it is extremely unlikely that oxyoctaline formate would be an irritant after 7 days and therefore would not be classifiable.