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EC number: 265-742-1 | CAS number: 65405-72-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Skin irritation
The skin irritation potential of the test substance was assessed in guinea pigs. After a single application of the test substance, 3 % in acetone does not irritate the skin. 10 % was the lowest irritant concentration after a single application of the test substance.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- The study was conducted in 1978.
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A single application of the test material was added to 2 cm2 of clipped skin on the flank of a guinea pig. Skin reactions were noted at 24 hours.
- GLP compliance:
- no
- Remarks:
- Study pre-dates GLP.
- Species:
- guinea pig
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
- Type of coverage:
- open
- Preparation of test site:
- clipped
- Vehicle:
- other: Acetone
- Controls:
- no
- Amount / concentration applied:
- 0.025 mL at concentrations of 3, 10, 30 and 100 %
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 hours
- Number of animals:
- No data
- Details on study design:
- A single application of 0.025 mL of each test concentration was simultaneously performed on an area measuring 2 cm2 of the flank of skin previously clipped and marked with a circular stamp.
The skin reactions were read 24 hours after application of the test material. The minimum and maximum non-irritant concentrations were determined by an all-or-none criterion. The minimal irritant concentration was defined as the lowest one causing skin irritation. The maximal non-irritant concentration was defined as the highest one not causing macroscopic skin irritation in any of the animals. - Irritation parameter:
- other: Lowest irritant concentration
- Basis:
- other: No data
- Time point:
- other: 24 h
- Score:
- 10
- Reversibility:
- no data
- Irritation parameter:
- other: Highest non-irritant concentration
- Basis:
- other: No data
- Time point:
- other: 24 h
- Score:
- 3
- Reversibility:
- no data
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- After a single application of the test substance, a 3% concentration in acetone does not cause skin irritation. Application of 10 % in acetone caused irritation.
After 7 days continuous application of the test item, only mild irritation was observed. - Executive summary:
The skin irritation potential of the test substance was assessed in guinea pigs.
After a single application of the test substance a 3% concentration in acetone did not irritate the skin.
A 10 % concentration was the lowest irritant concentration after a single application of the test substance.
This non-classification is based on the additional information after 21 days repeated dosing at 3%, 10%, 30% and 100% where after 7 days dosing at 100%, only slight irritation was observed.
Therefore after a single dose, it is extremely unlikely that oxyoctaline formate would be an irritant after 7 days and therefore would not be classifiable.
- Endpoint:
- skin irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro skin irritation study does not need to be conducted because adequate data from an in vivo skin irritation study are available
Referenceopen allclose all
Skin irritation after a single application
Solvent |
Lowest irritant concentration |
Highest non-irritant concentration |
Acetone |
10 % |
3 % |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation
The skin irritation potential of the test substance was assessed in guinea pigs. After a single application of the test substance, 3 % in acetone does not irritate the skin. 10 % was the lowest irritant concentration after a single application of the test substance.
Repeated applications of the test substance at 100 % resulted in irritation.
Justification for selection of skin irritation / corrosion
endpoint:
The study was conducted on the target substance in vivo in an
appropriate test species.
Effects on skin irritation/corrosion: slightly irritating
Justification for classification or non-classification
Skin irritation
Skin corrosion is defined as the production of irreversible damage to the skin following application of the test substance. Skin irritation is the production of reversible damage to the skin following application of the test substance. Substances can be allocated to one of two categories based on corrosive effects on the skin (Category 1) and irritation to the skin (Category 2) according to the Globally Harmonized Classification System and Regulation (EC) No. 1272/2008, relating to the Classification, Labelling and Packaging of Substances and Mixtures.
Animal irritant responses within a test can be quite variable. The criterion for classification as a skin irritant accommodates cases where there is a significant irritant response but less than the mean score criterion for a positive test. In this study single doses of the test substance were administered at low concentrations but were not graded in a manner which allows mean values for erythema or oedema to be calculated. Irritation was observed at a 10 % concentration and therefore higher concentrations are likely to also produce irritation scores. The test substance is therefore classified as a Category 2 skin irritant.
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