Registration Dossier
Registration Dossier
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EC number: 229-904-5 | CAS number: 6829-22-7
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Human patch test
Data source
Reference
- Reference Type:
- publication
- Title:
- Allergic contact dermatitis from a perinone-type dye C.I. Solvent Red 179 in spectacle frames
- Author:
- Tsunoda T, Kaniwa MA, Shuno M
- Year:
- 2 001
- Bibliographic source:
- Contact Dermatitis, 2001, 45, 166–167
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
- Principles of method if other than guideline:
- A patch test was performed with C.I. solvent Red 179 (CAS no 6829-22-7) on a 61-year old Japanese woman who developed itchy scaly erythema over the ears where the earpieces of her spectacle frames touched.
- GLP compliance:
- no
Test material
- Reference substance name:
- 14H-benz[4,5]isoquino[2,1-a]perimidin-14-one
- EC Number:
- 229-904-5
- EC Name:
- 14H-benz[4,5]isoquino[2,1-a]perimidin-14-one
- Cas Number:
- 6829-22-7
- Molecular formula:
- C22H12N2O
- IUPAC Name:
- 14H-benz[4,5]isoquino[2,1-a]perimidin-14-one
- Test material form:
- not specified
- Details on test material:
- no data
Constituent 1
Method
- Type of population:
- general
- Controls:
- yes
- Route of administration:
- dermal
Results and discussion
- Results of examinations:
- Positive reactions were obtained to scrapings of the earpieces, coloring agent 1% pet., Solvent Red 179 1% pet.(CAS no 6829-22-7) and Solvent Orange 60 1% pet. at D3. She was negative to Solvent Red 151. Control patch tests with scrapings, coloring agents and 3 dyes were negative in 5 normal
controls. The patient reacted to Solvent Red 179 and Solvent Orange 60, although the causative earpieces did not contain Solvent Orange 60. Thus, the reaction to Solvent Orange 60 in our case is concluded as being a cross-reaction with Solvent Red 179.
Any other information on results incl. tables
The 1st case of allergic contact dermatitis from C.I. Solvent Red 179 used in the earpieces of spectacle frames, with cross-reaction to C.I. Solvent Orange 60 is reported.
Applicant's summary and conclusion
- Executive summary:
In a case report of a 61-year-old Japanese woman who developed itchy scaly erythema over the ears where the earpieces of her spectacle touched, as allergic contact reagent C.I. Solvent Red 179 was identified in a patch test.
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