2-ethoxynaphthalene-1-carbonyl chloride

Endpoint summary

Description of key information

Short term toxicity to aquatic invertebrates:

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, toxicity on Daphnia magna was predicted for 2-Ethoxy-1-naphthoyl Chloride (55150-29-3). The EC50 value was estimated to be 383.529 mg/l when 2-Ethoxy-1-naphthoyl Chloride exposed to Daphnia magna for 48hrs. Based on this value it can be concluded that the substance 2-Ethoxy-1-naphthoyl Chloride is considered as nontoxic to aquatic environment as per the criteria mentioned in CLP regulation. 

Short term toxicity to aquatic algae:

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, toxicity on Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) was predicted for 2-Ethoxy-1-naphthoyl Chloride (55150-29-3). The EC50 value was estimated to be 469.790 mg/l when 2-Ethoxy-1-naphthoyl Chloride exposed to Pseudokirchneriella subcapitata for 72 hrs. Based on this value it can be concluded that the substance 2-Ethoxy-1-naphthoyl Chloride is considered as nontoxic to aquatic environment as per the criteria mentioned in CLP regulation. 

Additional information

Summarized result of toxicity of 2-Ethoxy-1-naphthoyl Chloride (55150-29-3) on the growth and other activity of aquatic invertebrates, algae and cyanobacteria by considering the data for target as well as RA chemical which was selected on the basis of structure similarity are as follows: 

Short term toxicity to aquatic invertebrates:

Based on the various experimental data and prediction data for the target chemical as well as RA chemical which was selected on the basis of structure similarity study have been reviewed to determine the toxic nature of 2-Ethoxy-1-naphthoyl Chloride (55150-29-3) on the mobility of daphnia magna. The studies are as mentioned below: 

In the first predicted weight of evidence report for the 2-Ethoxy-1-naphthoyl Chloride (55150-29-3) from SSS (QSAR, 2017) toxicity study was carried out. Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, toxicity on Daphnia magna was predicted for 2-Ethoxy-1-naphthoyl Chloride (55150-29-3). The EC50 value was estimated to be 383.529 mg/l when 2-Ethoxy-1-naphthoyl Chloride exposed to Daphnia magna for 48hrs. Based on this value it can be concluded that the substance 2-Ethoxy-1-naphthoyl Chloride is considered as nontoxic to aquatic environment as per the criteria mentioned in CLP regulation. 

 

Similarly in the second weight of evidence study for the read across (98-88-4) HSDB, GSBL, HPVIS, Kemikalli 2017, Study was conducted to determine the toxicity of chemical Benzoyl chloride on the mobility of Palaeomonetes pugio. Determination of short term toxicity of Benzoyl chloride on the growth of aquatic invertebrates Palaeomonetes pugio for 96hrs. Grass shrimp (Palaeomonetes pugio) were collected from wild populations in an estuary near Galveston Bay, Texas and were observed for a minimum of 10 days prior to testing. Bioassay containers were filled with 12 liters of dilution water. Test substance was added in the form of a stock solution in deionized water. Five grass shrimp were placed in each of two duplicate aquaria (10 fish/concentration). At 24 hr intervals, grass shrimp were observed for survival, and water tested for dissolved oxygen and temperature. At the end of the 96 hr exposure period, pH and test substance concentration was measured by electron capture gas chromatography (benzene: 15% ether extraction). With concentration versus mortality results, 96 hr LC50 and 95% confidence limits were calculated by Probit, Moving average, or Binomial test (depending on the number of partial kills observed). Based on the rate of mortality of Palaeomonetes pugio by the chemical benzyl chloride, the LC50 was 180 mg/l.  

 

Similarly in the third weight of evidence study for the read across 1,1' oxydiethane (60-29-7), HSDB 2017. Determination of short term toxicity of 1,1' oxydiethane on the Immobility and abnormal behavior (e.g., erratic swimming) of daphnia magna. Test was performed in the static system for 24 hrs. 100% Dilution water was used as a control. Total of 20 Daphnia magna per concentration tested and test performed in the duplicates. Based on the inhibition of mobility of daphnia magna by the chemical 1,1' oxydiethane the EC50 was 165 mg/l for 24hrs. Based on the immobility and EC50, 1,1' oxydiethane was consider as nontoxic and can be consider to be not classified as per the CLP classification criteria.

 

Similarly in the fourth weight of evidence study for the read across (98-13-5) SIDS dossier 2013, Study was conducted to determine the toxicity of chemical Phenyltrichlorosilane on the mobility of daphnia magna. Short term toxicity study of the chemical Phenyltrichlorosilane on the growth of daphnia magna. Test was performed according to the standard OECD guidelines. Toxicity was measured at the different concentrations 2.0, 4.3, 9.4, 20.7, 45.5 and 100 mg/L. solvent and one control was also run simultaneously. A 100 mg test item/L stock solution was prepared prior to test initiation by adding 352 μL of the dosing stock solution to 1600 mL dilution water using a Hamilton syringe. Prior to addition of the dosing stock solution, the glass beaker containing the dilution water was placed on a magnetic stirrer. The spiked solution was stirred continuously overnight. The pH of the solution was then adjusted to 7.01 with 1 N hydrochloric acid (HCl) and 1 N sodium hydroxide (NaOH). Thereafter, the stock solution was further diluted to a final volume of 2000 mL with dilution water, resulting in a solvent (THF) concentration of 0.10 mL/L. Nominal concentrations of 2.0, 4.3, 9.4, 20.7, 45.5 and 100 mg/L were prepared by dilution of the stock solution. And addition of THF to a final concentration of 0.1 mL/L. After the exposure of < 24 hours old daphnia’s to the Phenyltrichlorosilane, the NOEC was 9.4mg/l and EC50 was >100mg/l. based on the EC50 value the chemical was toxic and can be consider to be not classified as toxic as per the CLP classification criteria.

 

Thus based on the above data sources for target chemical 2-Ethoxy-1-naphthoyl Chloride (55150-29-3)  from various experimental studies and predicted studies from QSAR, HSDB, GSBL, HPVIS, Kemikalli, and SIDS dossier it was summarized that the chemical was nontoxic and can be consider to be not classified as toxic as per the CLP classification criteria. 

 

Short term toxicity to aquatic algae:

Based on the various experimental data and prediction data for the target chemical as well as RA chemical which was selected on the basis of structure similarity study have been reviewed to determine the toxic nature of 2-Ethoxy-1-naphthoyl Chloride (55150-29-3) on the growth of algae. The studies are as mentioned below: 

In the first predicted weight of evidence report for the 2-Ethoxy-1-naphthoyl Chloride (55150-29-3) from SSS (QSAR, 2017) toxicity study was carried out. Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the six closest read across substances, toxicity on Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) was predicted for 2-Ethoxy-1-naphthoyl Chloride (55150-29-3). The EC50 value was estimated to be 469.790 mg/l when 2-Ethoxy-1-naphthoyl Chloride exposed to Pseudokirchneriella subcapitata for 72 hrs. Based on this value it can be concluded that the substance 2-Ethoxy-1-naphthoyl Chloride is considered as nontoxic to aquatic environment as per the criteria mentioned in CLP regulation. 

 

Similarly in the second weight of evidence study for the read across 1,1 -dimethylpropyl methyl ether (994-05-8), HSDB 2017. Short term toxicity to Pseudokirchneriella subcapitata study was carried out for 72 hrs. The study was based on the effects of the test compound 1,1 -dimethylpropyl methyl ether on Pseudokirchneriella subcapitata (green algae) in a static fresh water system at a temperature of 22.6 – 23.9°C and pH of 7.9 – 9.7, respectively. Pseudokirchneriella subcapitata (green algae) was used as a test organism at an initial cell density of 1 × 104cells/ml.Based on the effect on population abundance of test organism Pseudokirchneriella subcapitata, the 72 hr EC50 value was determined to be > 100 mg/l, respectively. Thus, based on the EC50 value, it can be concluded that the substance 1,1 -dimethylpropyl methyl ether can be considered as non-toxic to Pseudokirchneriella subcapitata at environmentally relevant concentrations and can be considered to be not-classified as per the CLP classification criteria.

 

Similarly in the third weight of evidence study for the read across chemical Phenyltrichlorosilane (98-13-5), SIDS dossier 2013. Short term toxicity study of the chemical Phenyltrichlorosilane on the growth of green algae was observed by the exposure of chemical for 72hrs. Test was performed by static method in Erlenmeyer flasks with different concentrations 0, 6.25, 12.5, 25.0, 50.0 and 100 mg/L. A 100 mg test item/L stock solution was prepared prior to test initiation by adding 176 μL of the dosing stock solution to 800 mL algal medium using a Hamilton syringe. Thereafter, the stock solution was further diluted to a final volume of 1000 mL with algal medium, resulting in a solvent (THF) concentration of 0.10 mL/L. initial cells density was394 x 104 cells/mL. Cell concentration and all other parameters was checked and maintained. The growth rate and biomass was observed in the interval of 24hrs. After the 72hrs of exposure the NOEC was ≥ 100 mg/l and the EC50 was > 100 mg/l on the basis of biomass and growth rate. Thus based on the EC50, the chemical was nontoxic and can be consider to be not classified as toxic as per the CLP classification criteria.

 

Similarly in the fourth weight of evidence study for the read across 1,1 -dimethylpropyl methyl ether (994-05-8), from OECD SIDS Initial Assessment Report 2005. Short term toxicity to Pseudokirchneriella subcapitata study was carried out for 72 hrs. The study was based on the effects of the test compound 1,1 -dimethylpropyl methyl ether (CAS no. 994 -05 -8) on Pseudokirchneriella subcapitata (green algae) in a static fresh water system. Pseudokirchneriella subcapitata (green algae) was used as a test organism. Based on the effect on biomass and growth rate of test organism Pseudokirchneriella subcapitata, the 72 hr EC50 value was determined to be 230 and 780 mg/l and the 72 hr NOEC value was determined to be 77 mg/l, respectively. Thus, based on the EC50 value, it can be concluded that the substance 1,1 -dimethylpropyl methyl ether can be considered as non-toxic to Pseudokirchneriella subcapitata at environmentally relevant concentrations and can be considered to be not-classified as per the CLP classification criteria.

 

Thus based on the above data sources for target chemical 2-Ethoxy-1-naphthoyl Chloride (55150-29-3)  from various experimental studies and predicted studies from QSAR, HSDB, and OECD SIDS dossier it was summarized that the chemical was nontoxic and can be consider to be not classified as toxic as per the CLP classification criteria.

Thus based on the above data for toxicity to both aquatic invertebrates and algae, it was summarized that the chemical was nontoxic and can be consider to be not classified as toxic as per the CLP classification criteria.