2-ethoxynaphthalene-1-carbonyl chloride

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from peer reviewed journal

Data source

Reference

Reference Type:

publication

Title:

Pigmented contact dermatitis from azo dyes. I. Cross-sensitivity in humans.

Author:

TAKEHITO KGZUKA, MINORU TASHIR0, SHIGEHARU SANO, KEIICHI FUJIMOTO,
YUMI NAKAMURA, SEIICHI HASHIMOTO AND GEN NAKAMINAM.

Year:

1980

Bibliographic source:

Contact Dermatitis; Volume 6; Pg. no. 330-336; 1980.

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

A patch test was performed in human patients suffering from pigmented contact dermatitis caused by the commercial Brilliant Lake Red R for test chemical 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol (CAS No: 3118-97-6) to assess its irritation efficacy.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

1-(2,4-dimethylphenylazo)-2-naphthol

EC Number:

221-490-4

EC Name:

1-(2,4-dimethylphenylazo)-2-naphthol

Cas Number:

3118-97-6

Molecular formula:

C18H16N2O

IUPAC Name:

1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol

Details on test material:

SMILES:Cc1ccc(N=Nc2c3ccccc3ccc2O)c(C)c1

Specific details on test material used for the study:

- Name of test material (as cited in study report): C.I. Solvent orange 7
- Molecular formula: C18H16N2O
- Molecular weight : 276.337 g/mol
- Substance type: Organic
- Physical state: Solid
- Smiles : Cc1ccc(N=Nc2c(O)ccc3ccccc23)c(C)c1
- InChI: 1S/C18H16N2O/c1-12-7-9-16(13(2)11-12)19-20-18-15-6-4-3-5-14(15)8-10-17(18)21/h3-11,21H,1-2H3/b20-19

Test animals

Species:

other: Human

Strain:

other: Not applicable

Details on test animals or test system and environmental conditions:

No data available

Test system

Type of coverage:

occlusive

Preparation of test site:

not specified

Vehicle:

other: Petrolatum

Controls:

yes

Amount / concentration applied:

1%

Duration of treatment / exposure:

2 days

Observation period:

24 hours after patch removal

Number of animals:

8

Details on study design:

TEST SITE
- Area of exposure: back of each volunteers
- Type of wrap if used: Finn Chambers® on Scanpor® (Epitest, Ltd. Oy).
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure:24 hours

SCORING SYSTEM: Readings were made according to the ICDRG classification (Wilkinson et a!. 1970)

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

24 h

Score:

2

Max. score:

8

Reversibility:

not specified

Remarks on result:

positive indication of irritation

Remarks:

Readings were made according to the ICDRG classification (Wilkinson et a!. 1970) 24 h after the patches were removed.

Irritant / corrosive response data:

Two patients showed positive skin reaction.

Applicant's summary and conclusion

Interpretation of results:

Category 2 (irritant) based on GHS criteria

Conclusions:

Positive reactions were seen in 2 out of total 8 cases. Thus the test chemical 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol (CAS No: 3118-97-6) was considered to be irritating in human patients suffering from pigmented contact dermatitis caused by the commercial Brilliant Lake Red R.

Executive summary:

A patch test was performed in human patients suffering from pigmented contact dermatitis caused by the commercial Brilliant Lake Red R for test chemical 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol (CAS No: 3118-97-6) to assess its irritation efficacy.

 

The patch of 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol was applied onto the back of each patient for 24 hours by usingFinn Chambers® on Scanpor® (Epitest, Ltd. Oy). After removal of patch, skin reactions were assessed according to the ICDRG classification for 2 days.

 

Twenty-eight healthy female volunteers, aged 20 and 21, were also tested with the sample as controls. None gave a positive reaction.

 

Since thepositive reactions were seen in 2 out of total 8 cases,the test chemical1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol (CAS No: 3118-97-6)was considered to be irritating in human patients suffering from pigmented contact dermatitis caused by the commercial Brilliant Lake Red R.