Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-440-0 | CAS number: 95-68-1
Endpoint summary
Administrative data
Description of key information
Skin irritation: 1 key study / 1 supporting study available: not irritating
Eye irritation: 1 key study / 1 supporting study available: irritating/not irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
There are one key study and one supporting study available on the skin irritancy potential. 2,4 -Xylidine was tested for its skin irritant properties in 3 New Zealand white rabbits. The study was performed according to OECD Guideline 404 without any deviations. Effects on skin (mean erythema score 0.2 and mean edema score 0) were observed in the animals 24-72 hours after application. These signs were fully reversible within the 72 hours observation period.
There are one key and one supporting study available on the eye irritancy potential. 2,4 -Xylidine was tested for its eye irritant properties in 3 New Zealand White rabbits. The study was performed according to OECD Guideline 405. Effects on cornea, conjunctivae and iris were observed in the animals after application. These signs were fully reversible within 7 days.
Effects on eye irritation: irritating
Justification for classification or non-classification
With reference the reported scores and the full reversibility of the observed effects to the skin 2,4 -Xylidine has not to be classified as irritant to the skin according to the criteria laid down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).
With reference the reported scores and the full reversibility of the observed effects to the eyes 2,4 -Xylidine has to be classified as irritant to the eye (Xi (irritant), R36 - irritating to the eyes; Cat. 2, H319 - causes serious eye irritation) according to the criteria laid down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
