Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information


One study has been identified that examines the basic metabolites of 2,4 -Xylidine:

Male Beagles were orally dosed for one or 10 days with 2,4-Dimethylaniline at 25 mg/kg bw/d. Male Fischer 344 rats were gavaged with 2,4-Dimethylaniline at 117 mg/kg bw/d for the same time period. 24 h urine samples were analysed by GC and GC/MS. The major urinary metabolite of the test item in the dog was 6-Hydroxy-2,4-dimethylaniline. Minor metabolites included 4-Amino-3-methyl-benzoic acid and N,2,4-Trimethylaniline. Rats produced N-Acetyl-4-Amino-3-Methyl-Benzoic acid as the major metabolite and N,2,6-Trimethylaniline in small amounts.