Registration Dossier
Registration Dossier
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EC number: 202-440-0 | CAS number: 95-68-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Toxicokinetics
One study has been identified that examines the basic metabolites of 2,4 -Xylidine:
Male Beagles were orally dosed for one or 10 days with 2,4-Dimethylaniline at 25 mg/kg bw/d. Male Fischer 344 rats were gavaged with 2,4-Dimethylaniline at 117 mg/kg bw/d for the same time period. 24 h urine samples were analysed by GC and GC/MS. The major urinary metabolite of the test item in the dog was 6-Hydroxy-2,4-dimethylaniline. Minor metabolites included 4-Amino-3-methyl-benzoic acid and N,2,4-Trimethylaniline. Rats produced N-Acetyl-4-Amino-3-Methyl-Benzoic acid as the major metabolite and N,2,6-Trimethylaniline in small amounts.
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