Registration Dossier
Registration Dossier
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EC number: 229-846-0 | CAS number: 6784-13-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Ames test: Negative (OECD TG 471, GLP)
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Ames test: The substance is tested in the Ames test according to OECD TG 471 and following GLP. Salmonella typhimurium strains TA1535, TA1537, TA102, TA98 and TA100 were treated with the test material at seven dose levels, in triplicate, both with and without the addition of a rat liver homogenate metabolising system. The dose range was determined in a preliminary toxicity assay and was 1.5 to 1500 µg/plate in the first experiment. The experiment was repeated on a separate day using the same dose range as Experiment 1, fresh cultures of the bacterial strains and fresh test material formulations. The test material caused a visible reduction in the growth of the bacterial background lawn at and above 500 µg/plate both with and without metabolic activation. The test material was, therefore, tested up to the toxic limit. No test material precipitate was observed on the plates at any of the doses tested in either the presence or absence of S9-mix. No significant increases in the frequency of revertant colonies were recorded for any of the bacterial strains, with any dose of the test material, either with or without metabolic activation. The test substance was considered to be non-mutagenic under the conditions of this test.
Justification for classification or non-classification
Based on the results of the Ames test, the substance does not need to be classified for genotoxicity according to EU CLP (EC 1272/2008 and its amendments).
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