Registration Dossier
Registration Dossier
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EC number: 229-846-0 | CAS number: 6784-13-0
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: LD50 is >2000 mg/kg bw in an OECD TG 423
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 2 000 mg/kg bw
Additional information
Acute oral toxicity : The study was conducted to assess the acute oral toxicity of the test substance in accordance with OECD Guideline 423 in compliance with GLP. A group of three fasted females was treated with the test material at a dose level of 2000 mg/kg bw. This was followed by a further group of three fasted females at the same dose level. Based on the results from this dose level a further two groups of fasted females were treated at a dose level of 300 mg/kg bw. At 2000 mg/kg, one animal was found dead one day after dosing and one animal was killed in extremis at this time. Signs of systemic toxicity noted in animals treated at a dose level of 2000 mg/kg were hunched posture, ataxia, lethargy, pilo-erection, decreased respiratory rate, laboured respiration, loss of righting reflex, occasional body tremors, tiptoe gait and coma. Surviving animals treated at a dose level of 2000 mg/kg appeared normal two, three or six days after dosing. There were no signs of systemic toxicity noted in animals treated at a dose level of 300 mg/kg. The surviving animals showed expected gains in bodyweight over the study period. Abnormalities noted at necropsy of the animal that died during the study were abnormally red lungs, dark liver and dark kidneys. No abnormalities were noted at necropsy of animals that were killed in extremis or at the end of the study. The acute oral median lethal dose (LD50) of the test material in the female Sprague-Dawley CD strain rat was >2000 mg/kg bw.
Justification for classification or non-classification
The substance does not have to be classified for Acute oral toxicity according to EU CLP (EC No. 1272/2008 and its amendments).
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