Oligomeric reaction products of 4,4'-propane-2,2-diyldiphenol and 2-methyloxirane and 2-(chloromethyl)oxirane

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

10 August 2012 - 20 November 2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP compliant study conducted in accordance with international guidelines.

Justification for type of information:

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
Common functional groups and similar composition.

EP-4000s and the registered substance are very similar. They are UVBC substances and both are oligomeric reaction products of 4,4'-propane-2,2-diyldiphenol and 2-methyloxirane and 2-(chloromethyl)oxirane where constituents are structurally related. EP-4000s contains less than 0.1% monochlorinated constituents while the registered substance contains approximately 10% monochlorinated constituents. As these are otherwise structurally similar to other constituents it can be reasonably expected that EP-4000s and the registered substance will have essentially the same properties.

2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)

EP4000s:
Purity 79.7-90%, 3 main components F, E, C
Impurities:
5 known by-products 18%
6 unknown impurities 2.4%
Water 0.1%
Chlorinated impurities <0.1%

Aliphaticdiol diglycidyl ether:
Purity 92.57%, 3 main components F, E, C
Impurities:
5 known by-products (same identity as EP-400s) 14.37%
Water none
Two new impurities (I and J) 10.48% in total

Further details are provided in Section 13 Assessment Reports.

3. ANALOGUE APPROACH JUSTIFICATION

Read across all data – the presence of one chlorine atom in components comprising 10% of a relatively high molecular weight mixture will not have a significant effect on physicochemical properties. Furthermore, alky halides are known to have fire retardant properties and therefore impurities I and J will not confer any flammable properties. It is noted that the log Pow is determined on the three main components of EP-4000s which means if the test was repeated on the Aliphaticdiol diglycidyl ether the result would be the same as both substances have the same three main components.

Overall conclusion – no new information would be gained by testing Aliphaticdiol diglycidyl ether for physicochemical properties.

4. DATA MATRIX

Not applicable – read across based on similar composition for all physicochemical endpoints.

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling point/boiling range)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

method according to Siwoloboff

Key result

Atm. press.:

1 026 mBar

Decomposition:

yes

Decomp. temp.:

> 250 °C

Remarks on result:

other: No boiling was noted up to 250 °C.

The results of duplicate definitive boiling point determinations (at barometric pressure: 1026 mbar) were as follows:

As the boiling tubes were heated at 1°C/minute, the samples were observed to darken at temperatures above approximately 250°C, indicating decomposition. No boiling was noted.

Conclusions:

The boiling temperature was not determinable as the test substance decomposed at temperatures above approximately 250°C without boiling.

Description of key information

The substance decomposes at temperatures above approximately 250°C without boiling.

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

250 °C

Additional information

A boiling point determination was conducted as part of a package of physicochemical testing on EP-4000S (Huntingdon Life Sciences, 2012, Study CVJ0131). The study was conducted in compliance with GLP and the boiling point determination was performed according to EC and OECD test guidelines. The boiling temperature of EP-4000S was not determinable as the test substance decomposed at temperatures above approximately 250°C without boiling.

The result for the boiling point of EP-4000s will be taken as that for the registered substance

Justification for read across justification -

EP-4000s and the registered substance are very similar. They are UVBC substances and both are oligomeric reaction products of 4,4'-propane-2,2-diyldiphenol and 2-methyloxirane and 2-(chloromethyl)oxirane where consituents are structurally related. EP-4000s contains less than 0.1% monochlorinated constituents while the registered sustance contains approximately 10% monochlorinated constituents. As these are otherwise structurally similar to other constituents it can be reasonably expected that EP-4000s and the registered substance will have essentially the same physicochemcial properties.